| 刘慧民1,2，秦修远3，马晓原1,2，田鑫1,2， 台秀梅1,2，卢知浩3,高续1,2.蜂蜡基油包水乳液的制备及其在大米活性肽递送中的应用[J].中国油脂,2026,51(7):.[LIU Huimin1,2, QIN Xiuyuan3, MA Xiaoyuan1,2, TIAN Xin1,2,
TAI Xiumei1,2, LU Zhihao3，GAO Xu1,2.Preparation of beeswax-based water-in-oil emulsion and its application in the delivery of rice bioactive peptides[J].China Oils and Fats,2026,51(7):.] |
| 蜂蜡基油包水乳液的制备及其在大米活性肽递送中的应用 |
| Preparation of beeswax-based water-in-oil emulsion and its application in the delivery of rice bioactive peptides |
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投稿时间：2025-05-23 修订日期：2026-03-23 录用日期：2025-06-16
出版日期：2026-07-20
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| DOI：10.19902/j.cnki.zgyz.1003-7969.250254 |
| 中文关键词: 蜂蜡 W/O乳液 流变特性 透皮吸收；大米活性肽 |
| 英文关键词:beeswax W/O emulsion rheological property transdermal absorption rice bioactive peptides |
| 基金项目:中国轻工集团科技创新基金项目(ZQ2022JC-QN09) |
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| Author Name | Affiliation | | LIU Huimin1,2, QIN Xiuyuan3, MA Xiaoyuan1,2, TIAN Xin1,2,
TAI Xiumei1,2, LU Zhihao3，GAO Xu1,2 | 1.China Research Institute of Daily Chemistry Co. , Ltd. , Taiyuan 030001, China
2.Shanxi Key Laboratory
of Functional Surfactants, Taiyuan 030001, China
3.China National Research Institute of Food &
Fermentation Industries Co. , Ltd. , Beijing 100015, China |
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| 中文摘要: |
| 旨在为蜂蜡在化妆品与皮肤外用制剂领域的开发提供参考，以蜂蜡为油相增稠剂，制备了负载大米活性肽油包水（W/O）乳液，考察了蜂蜡含量、冷却工艺（自然冷却和搅拌冷却）对乳液结构以及流变特性的影响，并评价其体外透皮吸收性能。结果表明：随着蜂蜡含量的升高，W/O乳液稳定性逐渐提高，在自然冷却工艺下，蜂蜡含量为15%时乳液稳定不分层，而在搅拌冷却工艺下，蜂蜡含量为10%时乳液即可稳定不分层；通过对不同工艺制备W/O乳液的微观结构分析，提出了不同冷却工艺调控的蜂蜡稳定乳液的不同机制；蜂蜡稳定的W/O乳液均为剪切变稀的非牛顿流体，随着蜂蜡含量的增加，乳液表观黏度增加，结构的触变恢复程度降低，线性黏弹区变宽，体系稳定性增加；在大米活性肽负载量相同的条件下，W/O乳液对大米活性肽的透皮吸收性能优于水包油（O/W）乳液。综上，蜂蜡作为一种高效的油相增稠剂，可通过调控冷却工艺优化其在乳液中的分布，从而以较低用量实现稳定的W/O乳液体系，并在活性成分的透皮递送中展现出良好应用潜力。 |
| 英文摘要: |
| To provide a reference for the development of beeswax in cosmetics and topical dermatological formulations, water-in-oil (W/O) emulsions loaded with rice bioactive peptides were prepared using beeswax as an oil-phase thickener. The effects of beeswax content and cooling methods (natural cooling and stirring cooling) on the emulsion structure and rheological properties were investigated, and the in vitro transdermal absorption performance of the W/O emulsion was evaluated. The results showed that emulsion stability gradually increased with rising beeswax content. Under the natural cooling process, the emulsion remained stable and did not separate at a beeswax content of 15%, whereas under the stirring cooling process, the emulsion remained stable and did not separate at a beeswax content of 10%. Through microstructural analysis of emulsions prepared using different processes, distinct mechanisms were proposed for beeswax-stabilized emulsions regulated by different cooling processes. All beeswax-stabilized W/O emulsions exhibited shear-thinning non-Newtonian fluids. As the beeswax content increased, the apparent viscosity of the emulsion increased, the thixotropic recovery degree decreased, the linear viscoelastic region widened, and the stability of the system improved. Under the same loading amount of rice bioactive peptides, W/O emulsions exhibited superior transdermal absorption performance than the oil-in-water (O/W) emulsions. In summary, beeswax, as an effective oil-phase thickener, can have its distribution in emulsions optimized by adjusting the cooling process, thereby enabling the formation of stable W/O emulsion systems at low concentrations and demonstrating good potential for transdermal delivery of active ingredients. |
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