| 秦昱汉1,2,3, 初柏君1,2,3， 穆蕾1,2,3， 孙颖1,2,3， 张江旭1,2, 3，
王黎明1,2,3， 孟金凤1,2,3， 安泰1,2,3.体外消化吸收模型及其在膳食脂肪中应用的研究进展[J].中国油脂,2026,51(5):.[QIN Yuhan1,2,3, CHU Baijun1,2,3, MU Lei1,2,3, SUN Ying1,2,3,
ZHANG Jiangxu1,2,3, WANG Liming1,2,3, MENG Jinfeng1,2,3, AN Tai1,2,3.Research progress on in vitro digestion and absorption models and their applications in dietary fat[J].China Oils and Fats,2026,51(5):.] |
| 体外消化吸收模型及其在膳食脂肪中应用的研究进展 |
| Research progress on in vitro digestion and absorption models and their applications in dietary fat |
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| DOI：10.19902/j.cnki.zgyz.1003-7969.250344 |
| 中文关键词: 膳食脂肪 体外消化模型 体外吸收模型 Caco-2细胞 |
| 英文关键词:dietary fat in vitro digestion model in vitro absorption model Caco-2 cell |
| 基金项目: |
| 作者 | 单位 | | 秦昱汉1,2,3, 初柏君1,2,3， 穆蕾1,2,3， 孙颖1,2,3， 张江旭1,2, 3，
王黎明1,2,3， 孟金凤1,2,3， 安泰1,2,3 | 1.中粮营养健康研究院有限公司,北京 102209； 2.营养健康与食品安全北京市重点实验室,北京 102209；
3.老年营养食品研究北京市工程实验室,北京 102209 |
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| Author Name | Affiliation | | QIN Yuhan1,2,3, CHU Baijun1,2,3, MU Lei1,2,3, SUN Ying1,2,3,
ZHANG Jiangxu1,2,3, WANG Liming1,2,3, MENG Jinfeng1,2,3, AN Tai1,2,3 | 1.Nutrition & Health Institute, COFCO Corporation, Beijing 102209, China
2.Beijing Key
Laboratory of Nutrition & Health and Food Safety, Beijing 102209, China
3.Beijing Engineering
Laboratory for Geriatric Nutrition Food Research, Beijing 102209, China |
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| 中文摘要: |
| 膳食脂肪是维持人体功能的必需营养素，其摄入失衡与多种疾病密切相关，科学评估其消化吸收过程至关重要。为克服传统体内研究的局限性并为膳食脂肪体外消化吸收模型的构建与应用提供方法学参考，系统介绍了体外消化模型和吸收模型及其在膳食脂肪中应用的研究进展，并对未来发展方向进行展望。体外消化模型分为静态体外消化模型、半动态体外消化模型和动态体外消化模型3种。其中，静态体外消化模型操作简便，适用于脂肪消化的大规模初筛；半动态体外消化模型通过模拟胃相动态变化，可提供更深入的消化动力学信息；动态体外消化模型则高度还原胃肠道生理环境，在复杂膳食基质评估中展现出显著优势。Caco-2细胞模型是目前应用最广泛且经典的体外吸收模型之一，其能够实现从“生物可及性”向“生物利用度”的评价跨越。体外消化吸收模型在膳食脂肪中已被广泛应用，成为评估脂肪消化和吸收的有力工具，未来可从开发个性化定制模型、整合消化-器官芯片构建全链条仿生系统，以及建立标准化评价体系等方面进行深入探索。 |
| 英文摘要: |
| Dietary fat is an essential nutrient required for maintaining normal physiological functions in the human body, and its imbalanced intake is closely associated with a range of diseases, making the scientific evaluation of its digestion and absorption process critically important. To overcome the limitations of traditional in vivo studies and to provide methodological references for the construction and application of in vitro digestion and absorption models for dietary fat, the research progress on in vitro digestion and absorption models, along with their applications in dietary fat research were systematically introduced, and perspectives on future development directions were put forward. In vitro digestion models are classified into three categories: static in vitro digestion models, semi-dynamic in vitro digestion models, and dynamic in vitro digestion models. Static in vitro digestion models are straight forward to operate and are well-suited for large-scale preliminary screening of fat digestion. Semi-dynamic in vitro digestion models simulate the dynamic changes occurring during the gastric phase, thereby providing more in-depth information on digestion kinetics. Dynamic in vitro digestion models offer a high-fidelity reproduction of the gastrointestinal physiological environment and demonstrate significant advantages in the evaluation of complex food matrices. The Caco-2 cell model is currently one of the most widely used and well-established in vitro absorption models, capable of bridging the evaluation gap from "bioaccessibility" to "bioavailability". In vitro digestion and absorption models have been extensively applied in dietary fat research and have emerged as powerful tools for assessing fat digestion and absorption. Future research directions may include the development of personalized and customized models, the integration of digestion-on-a-chip and organ-on-a-chip technology to construct full-chain biomimetic systems, and the establishment of standardized evaluation frameworks. |
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