| 刘普芳，包音都古荣·金花，郭军，秦嘉杉，闫鑫磊.苏尼特羊尾油脂对小鼠溃疡性结肠炎的缓解作用研究[J].中国油脂,2026,51(5):.[LIU Pufang, BAOYINDUGURONG Jinhua, GUO Jun,
QIN Jiashan, YAN Xinlei.Alleviating effect of Sunite sheep tail oil on mice with ulcerative colitis[J].China Oils and Fats,2026,51(5):.] |
| Alleviating effect of Sunite sheep tail oil on mice with ulcerative colitis |
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| DOI：10.19902/j.cnki.zgyz.1003-7969.250116 |
| KeyWord:Sunite sheep tail oil ulcerative colitis inflammatory cytokines antioxidant intestinal barrier function gut microbiota |
| FundProject:内蒙古自治区科技计划项目（2021GG0348） |
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| Abstract: |
| In order to provide a reference for dietary intervention in intestinal inflammation, the alleviating effect of Sunite sheep tail oil (STO) on mice with ulcerative colitis (UC) was investigated. Male BALB/c mice were randomly and evenly divided into blank (NC) group, model (D) group, STO-D group, Sunite perirenal fat(SPF-D) group, lard (LO-D) group and rapeseed oil (RO-D) group. The first two groups were fed with normal diet, while the latter four groups were respectively fed with normal diet with 10% STO, Sunite perirenal fat, lard and rapeseed oil addition. The experiment lasted for 21 d. From 1-14 d, all mice had free access to water. From 15-21 d, the NC group continued with free drinking water, while the other groups were given 3.5% dextran sulfate sodium (DSS) solution to induce UC. The alleviating effect of STO on mice with UC was evaluated by analyzing basic growth conditions, colon histopathology, serum inflammatory cytokine levels, colonic oxidative stress indicators, immunohistochemistry, and gut microbiota composition. The results showed that STO alleviated colon shortening and body weight loss in UC mice and significantly reduced the disease activity index. STO also improved intestinal damage and inflammatory infiltration, promoting the restoration of colon tissue. STO intervention significantly decreased serum levels of TNF-α and IL-1β and colonic malondialdehyde (MDA) content (p<0.05), while increased colonic superoxide dismutase (SOD) activity (p<0.05). Furthermore, STO significantly upregulated the expression of cell junction proteins in the colon, including claudin-1, occludin, E-cadherin, and ZO-1 (p<0.05). Additionally, STO modulated the gut microbiota structure in UC mice by enriching potential beneficial bacteria such as Bacteroides and Parabacteroides, and restoring the Firmicutes/Bacteroidota ratio. In conclusion, the alleviating effect of STO on UC mice can be achieved by reducing inflammatory cytokines, enhancing the in vivo antioxidant capacity, regulating the intestinal barrier function, and optimizing the composition of the gut microbiota. |
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