| 孔海军，黄玲，王凤华，等.ω-3多不饱和脂肪酸对运动疲劳大鼠心肌细胞代谢、
抗氧化能力及血清IL-4、IL-6、INF-γ的影响[J].中国油脂,2017,42(8):.[KONG Haijun，HUANG Ling，WANG Fenghua，et al.Effects of ωω-3PUFAs on myocardial cell metabolism,antioxidant capacity and serum IL-4， IL-6 and INF-γ inrats with exercise induced fatigue[J].China Oils and Fats,2017,42(8):.] |
| ω-3多不饱和脂肪酸对运动疲劳大鼠心肌细胞代谢、
抗氧化能力及血清IL-4、IL-6、INF-γ的影响 |
| Effects of ωω-3PUFAs on myocardial cell metabolism,antioxidant capacity and serum IL-4， IL-6 and INF-γ inrats with exercise induced fatigue |
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| DOI： |
| 中文关键词: ω-3PUFAs 心肌细胞 抗氧化能力 能量节省化 |
| 英文关键词:ω-3PUFAs myocardial cell antioxidant capacity energy saving |
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| 中文摘要: |
| 探讨了ω-3PUFAs对大鼠心肌细胞代谢及血清T-SOD、MDA、血乳酸、LDH、IL-4、IL-6、INF-γ干预作用。将SD大鼠分为安静对照（Rc）组、运动对照（Mc）组、低剂量ω-3PUFAs灌胃（G1）组、中剂量ω-3PUFAs灌胃（G2）组和高剂量ω-PUFAs灌胃（G3）组。对SD大鼠进行8周递增负荷跑台运动复合ω-3PUFAs干预实验。结果表明：实验组大鼠心肌细胞高能磷酸化合物含量高于Mc组；实验组血清T-SOD活力呈现上升趋势;实验组MDA含量呈现下降趋势，G1组与Mc组比较具有显著差异（P<0.05），G2、G3组与Mc组比较具有极显著差异（P<0.01）；实验组血乳酸水平呈现下降趋势，G1、G2组与Mc组比较具有显著差异（P<0.05），G3组与Mc组比较具有极显著差异（P<0.01）；实验组LDH含量呈现上升现象，且LDH含量与ω-3PUFAs剂量呈正相关；实验组大鼠血清IL-4、IL-6、INF-γ水平低于Mc组。不同剂量ω-3PUFAs对大鼠心肌细胞代谢、抗氧化能力及血清IL-4、IL-6、INF-γ具有干预作用。 |
| 英文摘要: |
| In order to investigate the effects of ω-3PUFAs on the myocardial cell metabolism and the changes of serum T-SOD, MDA, blood lactate, LDH, IL-4, IL-6 and INF-纬 in rats, the SD rats were divided into sedentary control (Rc) group, exercise control (Mc) group, low dose ω-3PUFAs gavage(G1) group, medium dose ω-3PUFAs gavage(G2) group and high dose ω-3PUFAs gavage(G3) group, and a compound ω-3PUFAs intervention experiment by treadmill exercise for eight weeks was carried out. The results showed that the contents of high-energy phosphate compounds in experimental group were higher than those in Mc group. Serum T-SOD activity in experimental group showed an upward trend, while MDA content showed a downward trend, and G1 group had a significant difference with Mc group (P<0.05), G2 and G3 groups had highly significant differences with Mc group (P<0.01). Blood lactate levels in experimental group showed a downward trend. G1 and G2 groups had significant differences with Mc group (P<0.05), and G3 group had highly significant differences with Mc group(P<0.01). LDH content in experimental group showed an upward trend, and it was positively correlated with ω-3 PUFAs dose. Serum IL-4, IL-6, INF-γ levels in experimental group rats were lower than those in Mc group. Different doses of ω-3 PUFAs had intervention on the myocardial cell metabolism, antioxidant capacity and serum IL-4, IL-6, INF-γ in rats. |
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