| 杨浩，金小琬，唐嘉淇，等.裂殖壶菌合成二十二碳六烯酸机理研究进展[J].中国油脂,2019,44(8):.[YANG Hao,JIN Xiaowan,TANG Jiaqi,etc.Progress in mechanism of docosahexaenoic acid synthesis by Schizomycetes[J].China Oils and Fats,2019,44(8):.] |
| 裂殖壶菌合成二十二碳六烯酸机理研究进展 |
| Progress in mechanism of docosahexaenoic acid synthesis by Schizomycetes |
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| DOI： |
| 中文关键词: 裂殖壶菌 二十二碳六烯酸合成 培养条件 基因组测序 转录组测序 |
| 英文关键词:Schizochytrium DHA synthesis cultivation condition genome sequencing transcriptome sequencing |
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| 中文摘要: |
| 二十二碳六烯酸（DHA）属于ω-3不饱和脂肪酸，是保持人体健康的重要营养成分之一，具有重要的医药应用和营养价值。与植物和动物来源相比，裂殖壶菌合成DHA的工业应用前景广阔。研究表明，过表达聚酮合成酶（Polyketide synthase, PKS）和脂肪酸合成酶(Fatty acid synthase, FAS)途径中的关键作用酶基因与改变培养条件（如碳源、氮源、温度、无机盐、微量元素、前体物质及生物促进剂等），均可显著提高DHA产量。此外，不同限制条件下的裂殖壶菌基因组及转录组的测序分析，揭示了DHA合成过程种不饱和双键形成、信号传导、脂质转运及代谢的分子机制。 |
| 英文摘要: |
| Docosahexaenoic acid (DHA), which belongs to omega-3 unsaturated fatty acid, is one of the important nutrients for maintaining human health with potential medical applications. Compared with plant and animal sources, DHA synthesized by Schizomycetes has broaden the industrial application prospects. Studies showed that there were some promising ways to improve the DHA production, including over expressing the key enzymes of polyketide synthase (PKS) and fatty acid synthase (FAS) pathway, as well as optimizing the cultivation conditions (such as carbon sources, nitrogen sources, temperature, inorganic salts, trace elements, precursor substances and biological promoters). In addition, sequencing and analysis of the genome and transcriptome of Schizomycetes under different conditions further revealed the mechanism of DHA synthesis, corresponding to the unsaturated double bond formation, signal introduction, lipid transportation and metabolism. |
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