| 刘鸿铖.注射级玉米卵磷脂对高脂饮食大鼠的降血脂作用[J].中国油脂,2020,45(12):49~55.[LIU Hongcheng.Hypolipidemic effects of corn lecithin for injection on high-fat diet rats[J].China Oils and Fats,2020,45(12):49~55.] |
| 注射级玉米卵磷脂对高脂饮食大鼠的降血脂作用 |
| Hypolipidemic effects of corn lecithin for injection on high-fat diet rats |
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| DOI：10.12166/j.zgyz.1003-7969/2020.12.010 |
| 中文关键词: 注射级玉米卵磷脂 高脂饮食 大鼠 降血脂作用 |
| 英文关键词:corn lecithin for injection high-fat diet rat hypolipidemic effect |
| 基金项目:吉林省科技发展计划项目（20170204028NY） |
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| 中文摘要: |
| 探究注射级玉米卵磷脂（CLFI）对高脂膳食诱导的大鼠的降血脂作用。将60 只雄性SD大鼠随机分为6 组，即空白对照组、高脂模型组、阳性对照组（1.2 g/kg大豆卵磷脂）和CLFI高（2.4 g/kg）、中（1.2 g/kg）和低（0.6 g/kg）剂量组。除空白对照组给予基础饲料外，其余各组均给予高脂饲料，喂养2 周后开始对阳性对照组和CLFI各剂量组连续灌胃给药6 周，每天1 次。空白对照组和高脂模型组给予蒸馏水10 mL/kg。试验结束后考察大鼠血清血脂水平变化，检测大鼠体重、腹腔脂肪蓄积系数（AFC）、血清及肝脏中超氧化物歧化酶（SOD）活力和丙二醛（MDA）水平等指标，并观察肝脏的组织形态变化。结果表明：CLFI能有效抑制高脂膳食诱导大鼠的体重增长，降低血清中甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、MDA水平和动脉粥样硬化指数（AI）、血脂综合指数（LCI），并且降低AFC和肝脏中MDA水平；此外，高密度脂蛋白胆固醇（HDL-C）和SOD水平都有不同程度的提升，肝脏脂肪变性情况也得到改善。CLFI对高脂血症大鼠具有较好的降血脂和预防肝脏脂肪变性的作用，可为CLFI后续的开发和产业化应用提供一定的理论依据。 |
| 英文摘要: |
| The hypolipidemic effects of corn lecithin for injection (CLFI) on high-fat diet rats were investigated. Totally 60 male SD rats were randomly and equally divided into six groups: blank control group, high fat model group, positive control group (1.2 g/kg soybean lecithin), and high-, middle-and low-dose CLFI (2.4, 1.2, 0.6 g/kg) groups. The rats in the blank control group were fed with normal diet, while the remaining groups were fed with high-fat diet for two weeks. Then the positive control group and each CLFI dose group were administered by gavage with the corresponding drugs, and the blank control group and high fat model group were intragastrically administered the same volume of distilled water (10 mL/kg) once a day. After six weeks of feeding, serum lipid parameters, body weight, abdominal fat coefficient (AFC), superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in both serum and liver tissue of rats were determined, and morphological changes in the liver of rats were observed. The results showed that CLFI could inhibit body weight gain induced by high-fat diet in rats, and reduce serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), MDA,atherosclerosis index (AI), and lipid comprehensive index (LCI) levels in serum as well as AFC and hepatic MDA content. In addition, the levels of SOD and high-density lipoprotein cholesterol (HDL-C) could increase for varying degrees, and fatty degeneration of the liver was improved. CLFI had potent hypolipidemic and hepatoprotective effects in hyperlipidemic rats. This study provided a theoretical basis for the development and industrial application of CLFI. |
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