| 申思洋
苌建峰
柴逸飞
李娟
褚梦真
李连珍.红花籽油和紫苏籽油不同配比降血脂作用研究[J].中国油脂,2020,45(2):106~110.[SHEN Siyang
CHANG Jianfeng
CHAI Yifei
LI Juan
CHU Mengzhen
LI Lianzhen.Hypolipidemic effect of different proportions of safflower seed oil and perilla seed oil[J].China Oils and Fats,2020,45(2):106~110.] |
| 红花籽油和紫苏籽油不同配比降血脂作用研究 |
| Hypolipidemic effect of different proportions of safflower seed oil and perilla seed oil |
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| DOI：10.12166/j.zgyz.1003-7969/2020.02.021 |
| 中文关键词: 大鼠 小鼠 红花籽油 紫苏籽油 降血脂作用 |
| 英文关键词:rat mouse safflower seed oil perilla seed oil hypolipidemic effect |
| 基金项目:河南省高校重点科研项目（17A360006） |
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| 摘要点击次数: 2202 |
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| 中文摘要: |
| 探讨红花籽油和紫苏籽油不同配比的降血脂作用。将正常小鼠60只随机分为空白组、红花籽油、紫苏籽油、红花籽油与紫苏籽油配比1.18∶ 1、2.59∶ 1、5.42∶ 1组；将正常大鼠48只随机分为空白组、红花籽油与紫苏籽油配比0.47∶ 1、2.59∶ 1、4.01∶ 1、5.42∶ 1、8.25∶ 1组；空白组给予生理盐水，其余组给予对应配比的油，灌胃量10 mL/kg。灌胃30 d后，小鼠取血，大鼠取血及肝脏，检测总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）含量。结果表明：与空白组比，小鼠TG、TC含量红花籽油与紫苏籽油配比2.59∶ 1组、542∶ 1组均显著降低，2.59∶ 1组LDL-C含量显著降低，2.59∶ 1组、5.42∶ 1组HDL-C含量显著升高。与空白组相比，大鼠血清TG、TC含量红花籽油与紫苏籽油配比0.47∶ 1组、2.59∶ 1组显著或极显著降低，047∶ 1组、2.59∶ 1组LDL-C含量显著降低，2.59∶ 1组HDL-C含量显著升高。与空白组相比，大鼠肝脏TC含量红花籽油与紫苏籽油配比0.47∶ 1组、2.59∶ 1组显著或极显著降低，2.59∶ 1组和401∶ 1组TG含量极显著或显著降低，0.47∶ 1组、2.59∶ 1组LDL-C含量显著降低。红花籽油和紫苏籽油不同配比对正常动物血脂具有降低作用，其中红花籽油与紫苏籽油配比2.59∶ 1组降血脂作用最明显。 |
| 英文摘要: |
| The hypolipidemic effects of different proportions of safflower seed oil and perilla seed oil was explored. 60 normal mice were randomly divided into blank group, safflower seed oil, perilla seed oil and proportions of safflower seed oil to perilla oil 1.18∶ 1, 2.59∶ 1, 5.42∶ 1 groups, 48 normal rats were randomly divided into blank group, proportions of safflower seed oil to perilla seed oil 0.47∶ 1, 2.59∶ 1, 401∶ 1, 5.42∶ 1, 8.25∶ 1 groups. Blank group was given saline, the remaining groups were given the corresponding proportion of oil, and the amount of gavage dose was 10 mL/kg. After 30 d of gavage, mouse blood and rats blood and liver were taken, and the total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) levels were measured by total biochemical analyzer. The results showed that compared with blank group, TG and TC level of mice in 259∶ 1 group and 5.42∶ 1 group significantly decreased, LDL-C level in 2.59∶ 1 group had a significantly decrease, and HDL-C level in 2.59∶ 1 group and 5.42∶ 1 group had a significant increase. Compared with blank group, serum TG and TC levels of rats significantly decreased in 047∶ 1 group and very significantly decreased in 2.59∶ 1 group, LDL-C level in the two groups also markedly reduced. For HDL-C level, there was a significant increase in 2.59∶ 1 group. Compared with blank group, TC level of rat in liver significantly decreased in the 0.47∶ 1 group and very significantly decreased in 2.59∶ 1 group, TG level very significantly decreased in 2.59∶ 1 group and significantly decreased in 4.01∶ 1 group, and LDL-C level significantly decreased in 0.47∶ 1 group and 2.59∶ 1 group. Safflower seed oil and perilla seed oil in different proportions had a hypolipidemic effects on normal animals, and the hypolipidemic effect of 2.59∶ 1 group was the most obvious. |
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