| 于亚星1，2，鲁海龙3，孙尚德1，2，毕艳兰1，2.酚类抗氧化剂的主要转化产物
——醌的研究进展[J].中国油脂,2024,49(3):.[YU Yaxing1，2，LU Hailong3，SUN Shangde1，2，BI Yanlan1，2.Progress on quinones: A major transformation product of phenolic antioxidants[J].China Oils and Fats,2024,49(3):.] |
| 酚类抗氧化剂的主要转化产物
——醌的研究进展 |
| Progress on quinones: A major transformation product of phenolic antioxidants |
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| DOI： |
| 中文关键词: 抗氧化 生育醌 鼠尾草醌 迷迭香醌 表儿茶素类醌 叔丁基对苯醌 细胞毒性 |
| 英文关键词:antioxidation tocoquinone sage quinone rosemary quinone epigallocatechin quinone tert-butyl benzoquinone cytotoxicity |
| 基金项目:国家自然科学基金项目（32172131） |
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| 中文摘要: |
| 酚类抗氧化剂在抗氧化过程中的主要转化产物为醌类物质，为了更深入地了解这些醌类物质的特点，从化学结构、检测方法、抗氧化作用等方面总结常用抗氧化剂生育酚、鼠尾草酚、迷迭香酚、茶多酚、特丁基对苯二酚（TBHQ）的主要转化产物生育醌、鼠尾草醌、迷迭香醌、表儿茶素类醌及叔丁基对苯醌（TBBQ）的研究进展，另外，对一些醌类的细胞毒性进行了归纳。上述几种酚类抗氧化剂的转化产物醌类物质，多采用高效液相色谱法检测，它们中大部分具有抗氧化活性，有些则在一定条件下具有促氧化效果。目前，关于醌类细胞毒性的研究主要集中在TBBQ和生育醌。今后应加强醌类物质抗氧化作用、细胞毒性以及定量分析方法等方面的研究，以期为科学认识抗氧化剂和开发新型抗氧化剂奠定基础。 |
| 英文摘要: |
| The main transformation products of phenolic antioxidants in the antioxidant process are quinones. In order to gain a deeper understanding of the properties of these quinones, the progress of research on the main transformation products (tocoquinone, sage quinone, rosemary quinone, epigallocatechin quinone and tert-butyl benzoquinone (TBBQ)) of the commonly used antioxidants (tocopherol, carnosol, rosemanol, tea polyphenols and tert-butyl hydroquinone (TBHQ) ) was reviewed in terms of their chemical structures, detection methods, antioxidant activities, and the cytotoxicity of some of them. Quinones, the transformation products of the above phenolic antioxidants, are mostly detected by high performance liquid chromatography (HPLC) and most of them have antioxidant activity, while some have pro-oxidant effects under certain conditions. Currently, studies of quinone cytotoxicity mainly focus on TBBQ and tocoquinone. In the future, research on the antioxidant effects, cytotoxicity and quantitative analysis methods of quinones should be intensified to lay the foundations for the scientific understanding of antioxidants and the development of new antioxidants. |
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