张颖,张杏芳,闫雨蒙,张颖,沈旖凝,闫媛媛,李晓光.支链、奇数链脂肪酸与肠道健康的关联性研究[J].中国油脂,2024,49(7):.[ZHANG Ying, ZHANG Xingfang, YAN Yumeng, ZHANG Ying, SHEN Yining, YAN Yuanyuan, LI Xiaoguang.Association between branched/odd-chain fatty acids and intestinal health[J].China Oils and Fats,2024,49(7):.]
支链、奇数链脂肪酸与肠道健康的关联性研究
Association between branched/odd-chain fatty acids and intestinal health
  
DOI:
中文关键词:  支链脂肪酸  奇数链脂肪酸  肠道健康
英文关键词:branched-chain fatty acids  odd-chain fatty acids  intestinal health
基金项目:国家自然科学基金面上项目(81972820)
作者单位
张颖,张杏芳,闫雨蒙,张颖,沈旖凝,闫媛媛,李晓光 (上海交通大学医学院 公共卫生学院上海 200025) 
Author NameAffiliation
ZHANG Ying, ZHANG Xingfang, YAN Yumeng, ZHANG Ying, SHEN Yining, YAN Yuanyuan, LI Xiaoguang (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China) 
摘要点击次数: 1912
全文下载次数: 2745
中文摘要:
      为明确支链脂肪酸(BCFA)与奇数链脂肪酸(OCFA)对肠道健康的影响,利用气相色谱-质谱联用分析健康人群与肠道疾病患者血液中脂肪酸含量的差异,并应用正交偏最小二乘-判别分析(OPLS-DA)鉴定肠道健康人群的特征脂肪酸。结果表明:健康对照组、肠道息肉组、结直肠癌组3组人群中共检测出9种BCFA和4种OCFA;BCFA、OCFA含量在健康人群中显著偏高(p<005),其中anteiso-C17∶ 0、C17∶ 0含量随肠道健康状态恶化呈梯度下降趋势(p<0.05);OPLS-DA共鉴定出anteiso-C17∶ 0、iso-C17∶ 0、C18∶ 1、C18∶ 0、C16∶ 0、C14∶ 0 6种特征脂肪酸标志物。综上,BCFA和OCFA对肠道健康有潜在的保护作用。
英文摘要:
      To ascertain the effects of branched-chain fatty acids (BCFA) and odd-chain fatty acids (OCFA) on intestinal health, serum fatty acid contents in healthy population and patients with intestinal diseases were measured by gas chromatography-mass spectrometry. Orthogonal partial least-squares discrimination analysis(OPLS-DA)was used to identify characteristic fatty acid of intestinal healthy population. The results showed that 9 kinds of BCFA and 4 kinds of OCFA were detected in the healthy control group, intestinal polyp group and colorectal cancer group. The contents of BCFA and OCFA were significantly higher in healthy population(p<0.05), and the contents of anteiso-C17∶ 0 and C17∶ 0 showed a gradient decreasing trend with the deterioration of intestinal health status (p<0.05). OPLS-DA identified six characteristic fatty acid markers of anteiso-C17∶ 0, iso-C17∶ 0, C18∶ 1, C18∶ 0, C16∶ 0 and C14∶ 0. To sum up, BCFA and OCFA have a potential protective effect on intestinal health.
查看全文   查看/发表评论  下载PDF阅读器
关闭
《中国油脂》杂志社 官方网站
地址:西安市劳动路118号 邮编:710082
电话:029-88617441 88621360 88626849 传真:029-88625310
您是第13663292位访客  京ICP备09084417号