| 程芳园1，杨新月1，刘晓鹏2，王秀华1，李文娟1，韩娜1，宋秋月1.不同浓度DAG食用油对肥胖小鼠
代谢调控及肝脏功能的影响[J].中国油脂,2025,50(8):.[CHENG Fangyuan1, YANG Xinyue1, LIU Xiaopeng2, WANG Xiuhua1,
LI Wenjuan1, HAN Na1, SONG Qiuyue1.Impact of different concentrations of diacylglycerol edible oil on metabolic regulation and liver function in obese mice[J].China Oils and Fats,2025,50(8):.] |
| 不同浓度DAG食用油对肥胖小鼠
代谢调控及肝脏功能的影响 |
| Impact of different concentrations of diacylglycerol edible oil on metabolic regulation and liver function in obese mice |
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| DOI：10.19902/j.cnki.zgyz.1003-7969.240270 |
| 中文关键词: 甘油二酯；脂质代谢；抑制体质量增加；降低血糖 肝脏功能 |
| 英文关键词:diacylglycerol lipid metabolism inhibition of body weight gain reduction in blood glucose level liver function |
| 基金项目: |
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| Author Name | Affiliation | | CHENG Fangyuan1, YANG Xinyue1, LIU Xiaopeng2, WANG Xiuhua1,
LI Wenjuan1, HAN Na1, SONG Qiuyue1 | 1.Changshouhua Food Company Limited, Binzhou 256209，Shandong, China；
2. Binzhou Inspection and Testing Center, Binzhou 256600, Shandong, China |
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| 中文摘要: |
| 旨在为甘油二酯（DAG）在健康管理和疾病预防中的优化应用提供参考，通过饲喂雄性C57BL/6J系SPF级小鼠高脂高糖饲料建立肥胖小鼠模型，将肥胖模型组小鼠随机分为3组，分别以玉米油、40%DAG玉米油和80%DAG玉米油替代高脂高糖饲料中的猪油，饲喂16周，研究DAG食用油对肥胖小鼠体质量、血脂、肝脏功能的影响。结果表明：不同浓度的DAG食用油均能有效抑制小鼠体质量增加，减少白色脂肪积累，降低血清总胆固醇、甘油三酯及低密度脂蛋白胆固醇水平，同时提升高密度脂蛋白胆固醇水平，减少肝细胞脂肪变性，减轻小鼠肝脏损伤，还可以降低小鼠血清中葡萄糖含量，而且40%DAG食用油展现出相对于80%DAG食用油更优的效果。综上，DAG食用油可有效改善肥胖小鼠脂质代谢和肝脏功能，且在长期干预策略中，40%DAG食用油可能是更佳的选择。 |
| 英文摘要: |
| To provide a reference for the optimized application of diacylglycerol (DAG) in health management and disease prevention, an obese mice model was established by feeding male C57BL/6J SPF grade mice with a high-fat and high-sugar diet. The obese model group mice were randomly divided into three groups and fed for 16 weeks with high-fat and high-sugar diet where lard was replaced by corn oil, 40% DAG-enriched corn oil, and 80% DAG-enriched corn oil, respectively. The effects of DAG edible oils on body weight, blood lipids, and liver function in obese mice were investigated. The results demonstrated that different concentrations of DAG edible oils effectively inhibited body weight gain, reduced white adipose tissue accumulation, lowered serum levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, and increased high-density lipoprotein cholesterol levels. Additionally, DAG edible oils alleviated hepatic steatosis, mitigated liver damage, and decreased serum glucose content in mice. Notably, 40% DAG-enriched edible oil exhibited superior effects compared to 80% DAG-enriched edible oil. In conclusion, DAG-enriched edible oils can significantly improve lipid metabolism and liver function in obese mice, and in the long-term intervention strategy, 40% DAG-enriched oil may be a better choice. |
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