| 覃善嘉1，殷亚庆1，吴晶枝1，刘幽燕1,2.水热法木质素复合纳米粒子稳定的Pickering
乳液的环境稳定性及姜黄素释放性能[J].中国油脂,2025,50(10):.[QIN Shanjia1，YIN Yaqing1，WU Jingzhi1，LIU Youyan1,2.Environmental stability and curcumin release properties of Pickering emulsions stabilised by lignin composite nanoparticles by hydrothermal method[J].China Oils and Fats,2025,50(10):.] |
| 水热法木质素复合纳米粒子稳定的Pickering
乳液的环境稳定性及姜黄素释放性能 |
| Environmental stability and curcumin release properties of Pickering emulsions stabilised by lignin composite nanoparticles by hydrothermal method |
|
出版日期：
|
| DOI：10.19902/j.cnki.zgyz.1003-7969.240417 |
| 中文关键词: 木质素复合纳米粒子 Pickering乳液 稳定性 姜黄素 药物递送 |
| 英文关键词:lignin composite nanoparticles Pickering emulsion stability curcumin drug delivery |
| 基金项目:国家自然科学基金（21966007）；广西自然科学基金（2018GXNSFAA281278） |
|
|
| 摘要点击次数: 1531 |
| 全文下载次数: 697 |
| 中文摘要: |
| 为探究木质素复合纳米粒子在Pickering乳液中的应用，以碱木质素为原料，采用水热法制备木质素复合纳米粒子，并以其作为稳定剂制备Pickering乳液。分析了木质素复合纳米粒子及其稳定的Pickering乳液的稳定性，并将该Pickering乳液用于包封姜黄素，研究模拟胃肠道环境下姜黄素的释放性能，并采用4种动力学模型模拟姜黄素的释放行为。结果表明：水热法制备的木质素复合纳米粒子平均粒径约为150 nm，PDI为0.1，在pH 3~9范围内保持稳定的分散状态，具备一定的pH响应能力；在油相与水相体积比1∶ 9条件下制备的木质素复合纳米粒子Pickering乳液，其平均粒径为（3.781±1.661）μm，pH和离子浓度对该Pickering乳液的粒径均存在一定影响；姜黄素体外释放试验结果显示，在pH 2.5时姜黄素72 h的释放率为17%，在pH 7.4时释放率为88%。在pH 2.5下姜黄素释放行为更适合First-order模型，在pH 7.4下姜黄素释放行为更适合Ritger-Peppas模型。综上，木质素复合纳米粒子尺寸均一、分散性好，表现出一定的pH响应能力，制备的木质素复合纳米粒子Pickering乳液稳定，具有一定的环境稳定性，药物控释效果好，可成为输送生物活性化合物的有效途径。 |
| 英文摘要: |
| In order to investigate the application of lignin composite nanoparticles in Pickering emulsions, lignin composite nanoparticles were prepared by hydrothermal method using alkali lignin as a raw material, which was used as a stabilising agent for the preparation of Pickering emulsions. The stabilities of lignin composite nanoparticles and their stabilised Pickering emulsions were analyzed, the Pickering emulsions were used to encapsulate curcumin, the release properties of curcumin under simulated gastrointestinal environmental conditions were investigated, and four kinetic models were used to simulate the release behaviour of curcumin. The results showed that the lignin composite nanoparticles prepared by hydrothermal method had an average particle size of 150 nm, a PDI of 0.1, maintained a stable dispersion in the pH 3-9, and had certain pH responsiveness. Pickering emulsion with an average particle size of （3.781±1.661） μm could be obtained under the oil/water phase ratio of 1∶ 9. In addition, both pH and ion concentration affected the particle size of the Pickering emulsions. The results of in vitro curcumin release experiments showed that the release rate of curcumin for 72 h was 17% at pH 2.5 and 88% at pH 7.4.The curcumin release behavior at pH 2.5 was more suitable for First-order model and curcumin release behavior at pH 7.4 was more suitable for Ritger-Peppas model. In conclusion, lignin composite nanoparticles are uniform in size, well dispersed and show certain pH responsiveness, the prepared lignin composite nanoparticles Pickering emulsion is stable and has some environmental stability, the controlled release of the drug is good and it can be an effective way of delivering bioactive compounds. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
