| 覃善嘉1，殷亚庆1，吴晶枝1，刘幽燕1,2.水热法木质素复合纳米粒子稳定的Pickering
乳液的环境稳定性及姜黄素释放性能[J].中国油脂,2025,50(10):.[QIN Shanjia1，YIN Yaqing1，WU Jingzhi1，LIU Youyan1,2.Environmental stability and curcumin release properties of Pickering emulsions stabilised by lignin composite nanoparticles by hydrothermal method[J].China Oils and Fats,2025,50(10):.] |
| Environmental stability and curcumin release properties of Pickering emulsions stabilised by lignin composite nanoparticles by hydrothermal method |
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Published：
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| DOI：10.19902/j.cnki.zgyz.1003-7969.240417 |
| KeyWord:lignin composite nanoparticles Pickering emulsion stability curcumin drug delivery |
| FundProject:国家自然科学基金（21966007）；广西自然科学基金（2018GXNSFAA281278） |
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| Abstract: |
| In order to investigate the application of lignin composite nanoparticles in Pickering emulsions, lignin composite nanoparticles were prepared by hydrothermal method using alkali lignin as a raw material, which was used as a stabilising agent for the preparation of Pickering emulsions. The stabilities of lignin composite nanoparticles and their stabilised Pickering emulsions were analyzed, the Pickering emulsions were used to encapsulate curcumin, the release properties of curcumin under simulated gastrointestinal environmental conditions were investigated, and four kinetic models were used to simulate the release behaviour of curcumin. The results showed that the lignin composite nanoparticles prepared by hydrothermal method had an average particle size of 150 nm, a PDI of 0.1, maintained a stable dispersion in the pH 3-9, and had certain pH responsiveness. Pickering emulsion with an average particle size of （3.781±1.661） μm could be obtained under the oil/water phase ratio of 1∶ 9. In addition, both pH and ion concentration affected the particle size of the Pickering emulsions. The results of in vitro curcumin release experiments showed that the release rate of curcumin for 72 h was 17% at pH 2.5 and 88% at pH 7.4.The curcumin release behavior at pH 2.5 was more suitable for First-order model and curcumin release behavior at pH 7.4 was more suitable for Ritger-Peppas model. In conclusion, lignin composite nanoparticles are uniform in size, well dispersed and show certain pH responsiveness, the prepared lignin composite nanoparticles Pickering emulsion is stable and has some environmental stability, the controlled release of the drug is good and it can be an effective way of delivering bioactive compounds. |
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