| 栾俊琦1，郭建波1，张思琦2，吕静仪2，辛杭书2.奇链脂肪酸来源、合成途径及生物学活性研究进展[J].中国油脂,2025,50(10):.[LUAN Junqi1， GUO Jianbo1， ZHANG Siqi2， LYU Jingyi2， XIN Hangshu2.Research progress on sources, synthesis pathways and biological activities of odd-chain fatty acids[J].China Oils and Fats,2025,50(10):.] |
| 奇链脂肪酸来源、合成途径及生物学活性研究进展 |
| Research progress on sources, synthesis pathways and biological activities of odd-chain fatty acids |
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出版日期：
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| DOI：10.19902/j.cnki.zgyz.1003-7969.240336 |
| 中文关键词: 奇链脂肪酸 来源 生物合成 生物学活性 |
| 英文关键词:odd-chain fatty acids source biological synthesis biological activity |
| 基金项目:财政部和农业农村部国家现代农业产业技术体系资助（CARS36） |
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| 中文摘要: |
| 旨在为奇链脂肪酸（OCFA）的应用提供参考，对OCFA的来源、合成途径以及生物学活性进行了综述，并对OCFA的未来研究方向进行展望。OCFA主要来源于反刍动物的乳、乳制品，植物和微生物；内源性合成OCFA主要通过丙酰辅酶A作为前体的链延伸和偶链脂肪酸经α-氧化的链缩短来实现，人工合成则主要依赖基因工程技术和发酵技术；OCFA具有抗炎、降脂、降低心血管疾病和2型糖尿病风险等生物学活性。未来需进一步在分子水平上探究OCFA的作用机制，同时通过多种技术实现OCFA的大规模合成。 |
| 英文摘要: |
| The aim is to provide a reference for the application of odd-chain fatty acids (OCFA) by summarizing their sources, synthesis pathways and biological activities, and offering future perspectives on research direction. OCFA are primarily derived from ruminant milk and its dairy products, plants, and microorganisms. Endogenous synthesis of OCFA is mainly achieved through chain elongation using propionyl-CoA as a precursor and chain shortening of even-chain fatty acids via α-oxidation. Artificial synthesis predominantly relies on genetic engineering and fermentation technologies. OCFA exhibit biological activities such as anti-inflammatory effects, lipid-lowering properties, and reduced risks of cardiovascular diseases and type 2 diabetes. Future research should focus on elucidating the molecular mechanisms of action of OCFA and developing diverse technologies to enable their large-scale synthesis. |
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