| 王译民1，樊宁1，阿不都沙拉木·阿不都外力1，张杏芳1，
常黎俊1，于泉2，卞政3，闫媛媛1，王慧1.奇数链脂肪酸的分布、内源性合成及其与疾病发生
发展关系的研究进展[J].中国油脂,2026,51(1):.[WANG Yimin1， FAN Ning1， ABUDUSHALAMU Abuduwaili1， ZHANG Xingfang1，
CHANG Lijun1， YU Quan2， BIAN Zheng3， YAN Yuanyuan1， WANG Hui1.Research progress on the distribution, endogenous synthesis and association with disease development of odd-chain fatty acids[J].China Oils and Fats,2026,51(1):.] |
| 奇数链脂肪酸的分布、内源性合成及其与疾病发生
发展关系的研究进展 |
| Research progress on the distribution, endogenous synthesis and association with disease development of odd-chain fatty acids |
| |
| DOI：10.19902/j.cnki.zgyz.1003-7969.240320 |
| 中文关键词: 奇数链脂肪酸 分布 合成途径 生理功能 疾病作用 |
| 英文关键词:odd-chain fatty acids distribution synthesis pathway physiological function effects on diseases |
| 基金项目:上海交通大学“交大之星”计划医工交叉研究基金（YG2025LC14） |
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| Author Name | Affiliation | | WANG Yimin1， FAN Ning1， ABUDUSHALAMU Abuduwaili1， ZHANG Xingfang1，
CHANG Lijun1， YU Quan2， BIAN Zheng3， YAN Yuanyuan1， WANG Hui1 | (1.School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025,
China； 2.Department of Nutrition, Jinshan Hospital, Fudan University, Shanghai 201508, China；
3.Department of Obstetrics and Gynecology, Tongren Hospital, Shanghai Jiao Tong
University School of Medicine, Shanghai 200336, China) |
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| 摘要点击次数: 1977 |
| 全文下载次数: 427 |
| 中文摘要: |
| 为推动奇数链脂肪酸（OCFA）向营养干预靶点的转化应用，系统综述了OCFA的分布、内源性合成途径及其在疾病发生发展中的作用。OCFA天然存在于微生物、植物油、鱼类、牛羊乳及人体中，可通过支链氨基酸或短OCFA延长、超长偶数链脂肪酸α-氧化、植物鞘氨醇（PHS）脂类代谢、肝脏代谢丙酸盐等4条途径内源性合成；OCFA对糖尿病、心血管疾病、癌症、慢性炎症等疾病具有积极作用。OCFA可能通过多靶点调控降低慢性疾病风险，但OCFA的作用在不同疾病及人群间存在异质性，未来需深化机制研究并推进临床转化验证。 |
| 英文摘要: |
| To advance the convert application of odd-chain fatty acids (OCFA) as targets for nutritional intervention, the distribution, endogenous synthesis pathways, and roles of OCFA in diseases development were systematically summarized. OCFA are naturally present in microorganisms, vegetable oils, fish, bovine and ovine milk, and human body. They can be endogenously synthesized through four pathways: elongation of branched-chain amino acids or short-odd-chain fatty acids, α-oxidation of very-long-even-chain fatty acids, metabolism of phytosphingosine (PHS)-containing lipids, and hepatic metabolism of propionate. OCFA demonstrate beneficial effects against various diseases, including diabetes, cardiovascular diseases, cancer, and chronic inflammation. OCFA may reduce the risk of chronic diseases via multi-target regulation, but their effects vary across diseases and populations. Future research should focus on elucidating their mechanisms and advancing clinical validation. |
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