| 袁文涛，黄辉其，孙海辉，代志凯.溶剂结晶法制备高含量单体豆甾醇的工艺优化[J].中国油脂,2026,51(4):.[YUAN Wentao, HUANG Huiqi, SUN Haihui,DAI Zhikai.Optimization of the process for preparing high-purity stigmasterol monomer by solvent crystallization[J].China Oils and Fats,2026,51(4):.] |
| 溶剂结晶法制备高含量单体豆甾醇的工艺优化 |
| Optimization of the process for preparing high-purity stigmasterol monomer by solvent crystallization |
| |
| DOI：10.19902/j.cnki.zgyz.1003-7969.250063 |
| 中文关键词: 豆甾醇 植物甾醇 重结晶 正丁醇 |
| 英文关键词:stigmasterol phytosterols recrystallization n-butanol |
| 基金项目:宜春市重大研发专项(2023ZDYFZX03);江西省重点研发计划项目（20223BBF61022）;江西省国家科技进步奖培育项目（20223AEI91006） |
|
|
| 摘要点击次数: 386 |
| 全文下载次数: 202 |
| 中文摘要: |
| 旨在为工业化放大生产豆甾醇单体提供参考，以大豆油脱臭馏出物中提取的植物甾醇为原料，采用溶剂结晶法对其中的豆甾醇单体进行分离纯化，并通过单因素实验对豆甾醇分离纯化工艺条件进行优化。结果表明：豆甾醇单体的最优制备工艺条件为以正丁醇为溶剂，养晶温度8 ℃，养晶时间12 h，第1~6次重结晶的料溶比分别为1∶ 2、1∶ 3、1∶ 4、1∶ 4、1∶ 5、1∶ 6，第7次采用无水乙醇进行重结晶以消除正丁醇溶剂的影响，第7次料溶比为1∶ 10。在最优工艺条件下，豆甾醇含量由原料的29.15%提升至产品的96.04%，豆甾醇回收率为5.99%。综上，采用溶剂重结晶法可以获得高纯度的豆甾醇单体产品。 |
| 英文摘要: |
| To provide a reference for the industrial-scale production of stigmasterol monomer, phytosterols extracted from soybean oil deodorizer distillate were used as raw material, the stigmasterol monomer was purified by solvent crystallization, and the purification process conditions were optimized through single-factor experiments. The results showed that the optimal preparation conditions for stigmasterol monomer were as follows: using n-butanol as the solvent, crystallization temperature 8 ℃, crystallization time 12 h, and material-solvent ratios for the 1st to 6th recrystallization steps being 1∶ 2, 1∶ 3, 1∶ 4, 1∶ 4, 1∶ 5, and 1∶ 6, respectively. Anhydrous ethanol was used for the 7th recrystallization to eliminate the influence of n-butanol solvent, with a material-solvent ratio of 1∶ 10. Under these optimal conditions, the stigmasterol content increased from 29.15% in the raw material to 96.04% in the product, with a stigmasterol recovery rate of 5.99%. In conclusion, high-purity stigmasterol monomer product can be obtained using the solvent recrystallization method. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
