| 王艳艳，杨帆，王凤丽，冯秋芳，王东旭，曾坤，谷贵章.EMR-Lipid/MWCNTs-OH改进的QuEChERS法
结合UHPLC-MS/MS测定食用植物油中
54种农药及代谢物残留[J].中国油脂,2026,51(8):.[WANG Yanyan, YANG Fan, WANG Fengli, FENG Qiufang,
WANG Dongxu, ZENG Kun, GU Guizhang.Determination of 54 pesticides and metabolites in edible vegetable oils by UHPLC-MS/MS with EMR-Lipid/MWCNTs-OH modified QuEChERS[J].China Oils and Fats,2026,51(8):.] |
| Determination of 54 pesticides and metabolites in edible vegetable oils by UHPLC-MS/MS with EMR-Lipid/MWCNTs-OH modified QuEChERS |
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投稿时间：2025-12-19 修订日期：2026-03-23 录用日期：2026-01-12
Published：
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| DOI：10.19902/j.cnki.zgyz.1003-7969.250528 |
| KeyWord:EMR-Lipid MWCNTs-OH QuEChERS UHPLC-MS/MS edible vegetable oil pesticides and metabolites |
| FundProject:浙江省市场监督管理局科研计划项目（ZC2023078） |
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| Abstract: |
| To effectively eliminate matrix interference and enable the simultaneous determination of multiple pesticide residues in edible vegetable oils, an analytical method was established using a QuEChERS pretreatment modified with enhanced matrix removal lipid (EMR-Lipid) and hydroxylated multi-walled carbon nanotubes (MWCNTs-OH), combined with ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) for the simultaneous determination of residues of 54 pesticides and their metabolites in edible vegetable oils. Samples were extracted with 1% ammonia in acetonitrile. The extract was successively purified with EMR-Lipid and MWCNTs-OH. Separation was performed on a ZORBAX Eclipse Plus C18 column using gradient elution with 1.0 mmol/L ammonium formate in water (containing 0.01% formic acid) and 1.0 mmol/L ammonium formate in methanol (containing 0.01% formic acid). Detection was carried out using gas-assisted electrospray ionization in positive ion mode with multiple reaction monitoring (MRM), and quantification was performed by the external standard method. The results showed that the 54 pesticides and their metabolites exhibited good linearity in the mass concentration range of 2-500 ng/mL, with coefficients of determination greater than 0.998. The limits of detection ranged from 0.002 mg/kg to 0.005 mg/kg, and the limits of quantification ranged from 0005 mg/kg to 0.018 mg/kg. At three spiked levels of 0.05, 0.30 mg/kg and 1.50 mg/kg, the average recoveries of the 54 pesticides and their metabolites ranged from 70.4% to 109.8%, with relative standard deviations of 0.4%-8.9%. The method is simple to operate, rapid, and offers high sensitivity and accuracy, making it suitable for the rapid simultaneous determination of multiple pesticides and metabolite residues in edible vegetable oils. |
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