| 李玉珍, 肖怀秋，姜明姣，等.响应面优化微波固相合成花生肽亚铁金属配位螯合工艺[J].中国油脂,2017,42(9):.[LI Yuzhen, XIAO Huaiqiu, JIANG Mingjiao, et al.Optimization of microwave solid-phase synthesis of peanut peptide-ferrous metal coordination chelating technology by response surface methodology[J].China Oils and Fats,2017,42(9):.] |
| 响应面优化微波固相合成花生肽亚铁金属配位螯合工艺 |
| Optimization of microwave solid-phase synthesis of peanut peptide-ferrous metal coordination chelating technology by response surface methodology |
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| DOI： |
| 中文关键词: 花生肽亚铁配位螯合 微波固相催化 响应面优化 |
| 英文关键词:peanut peptide-ferrous coordination chelation microwave solid-phase catalysis response surface methodology optimization |
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| 中文摘要: |
| 以花生肽（相对分子质量＜3.0 kD）为原料，以硫酸亚铁（FeSO4·7H2O）为金属螯合剂，利用微波固相合成技术在单因素试验基础上，采取中心复合响应面法对花生肽亚铁配位螯合工艺进行了优化，建立了花生肽亚铁配位螯合工艺的二阶多项式非线性回归方程和数值模型，分析了微波辐射时间、花生肽亚铁配体比和引发剂用量对花生肽亚铁配位螯合的影响。结果表明，最佳花生肽亚铁配位螯合工艺为：微波辐射时间153 s，花生肽亚铁配体比5∶1，引发剂（H2O）用量3%，微波辐射功率608 W，反应物粒径120目，2.5%白炭黑（占花生肽质量）为脱酸剂，0.3%异抗坏血酸钠（占硫酸亚铁质量）为亚铁保护剂。在最佳条件下螯合率为（90.68±1.31）%，与模型预测值92.71%基本吻合。研究表明，以微波固相合成技术进行花生肽亚铁固相催化制备肽金属配位螯合营养强化剂可行。 |
| 英文摘要: |
| To promote the coordination chelation of peanut peptide and ferrous, peanut peptide (relative molecular weight less than 3.0 kD) and ferrous sulfate (FeSO4·7H2O) were used as reactant and mental chelator, respectively. A central composite design response surface methodology (CCD-RSM) was utilized to optimize peanut peptide-ferrous coordination chelation process using microwave solid-phase synthesis technology based on single factor experiment. The influences of microwave radiation time, peanut peptide-ferrous ratio and initiator dosage on peanut peptide-ferrous coordination chelation were investigated, and a second-order polynomial nonlinear regression equation and mathematical model were established. The results showed that the optimal peanut peptide-ferrous coordination chelation process conditions were obtained as follows: microwave radiation time 153 s, peanut peptide-ferrous ratio 5∶1, initiator dosage 3%, microwave radiation power 608 W, reactant particle size 120 meshes, using 2.5% of carbon-white as deacidification agent (based on the mass of peanut peptide) and 0.3% of sodium isoascorbate as ferrous protective agent (based on the mass of ferrous sulfate). Under these conditions, the chelating rate was (90.68±1.31)%, and was consistent with the predictive value (92.71%). The research indicated that microwave solid-phase synthesis technology was an efficient and promising means for the solid-phase catalytic preparation of metal nutrition supplement from peanut peptide and ferrous. |
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