| 严思思，刘水平，肖海思，等.植物油与猪油的调和油对小鼠血脂和肾功能的影响[J].中国油脂,2017,42(10):.[YAN Sisi, LIU Shuiping, XIAO Haisi，etc.Effect of vegetable oil and lard blend oil on blood lipid and renal function of mice[J].China Oils and Fats,2017,42(10):.] |
| 植物油与猪油的调和油对小鼠血脂和肾功能的影响 |
| Effect of vegetable oil and lard blend oil on blood lipid and renal function of mice |
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| DOI： |
| 中文关键词: 猪油 玉米油 大豆油 调和油 血脂 肾功能 心血管 |
| 英文关键词:lard corn oil soybean oil blend oil blood lipid renal function cardiovascular |
| 基金项目: |
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| 摘要点击次数: 1083 |
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| 中文摘要: |
| 以小鼠为模型模拟我国居民膳食习惯，探讨两种水平的玉米油与猪油的调和油、大豆油与猪油的调和油对小鼠体重、体脂率、血脂、血糖、肾功能、主动脉弓病理组织形态的影响。将40只8周龄雄性C57BL/6J小鼠随机均分为玉米油与猪油调和油推荐摄入量组（CR）、玉米油与猪油调和油实际摄入量组（CA）、大豆油与猪油调和油推荐摄入量组（SR）、大豆油与猪油调和油实际摄入量组（SA），每组的基础日粮中分别添加3.8%玉米油与猪油的调和油、6.5%玉米油与猪油的调和油、3.8% 大豆油与猪油的调和油、6.5%大豆油与猪油的调和油，饲喂8周后进行称重、解剖，采集外周血清检测血脂、血糖、肾功能，取主动脉弓做HE病理切片。结果表明：SA组的体重、体脂率均极显著高于CA组(P＜0.01)，SA组的脂联素含量极显著低于CA组(P＜0.01)，SA组的LDL-C含量显著高于CA组(P＜0.05)，SA组的尿酸含量、尿素含量、肌酐含量均极显著高于CA组(P＜0.01)；SA组的体重、体脂率、HDL-C含量、LDL-C含量、尿酸含量、尿素含量、肌酐含量均极显著高于SR组(P＜0.01)；各组主动脉弓病理组织切片均未观察到病变。表明在我国居民当前烹调油摄入水平下，与大豆调和油比较，选择玉米调和油能明显降低体重和体脂率，同时能有效改善血清LDL-C含量，降低患心血管疾病的风险。并且与玉米调和油比较，摄入更高剂量的大豆调和油更易促进肥胖并造成肾功能损伤。 |
| 英文摘要: |
| The effects of two levels of blend oil of lard and corn oil or soybean oil on body weight, body fat rate, blood lipid, blood glucose, renal function and aortic arch in mice were investigated by simulating Chinese dietary habits. A total of 40 eight weeks male C57BL/6J mice were randomly divided into four groups respectively fed with 3.8% corn oil and lard blend oil (recommended intake group,CR), 6.5% corn oil and lard blend oil (actual intake group, CA), 3.8% soybean oil and lard blend oil (recommended intake group,SR), and 6.5% soybean oil and lard blend oil (actual intake group, SA). After eight weeks, body weight was measured, peripheral blood was collected for determining blood lipid, serum glucose and renal function, and aortic arch was made HE pathology. The results showed that the body weight and body fat rate in SA were very significantly higher than that in CA (P＜0.01). The adiponcetin content in SA was very significantly lower than that in CA (P＜0.01). The SA had higher LDL-C level than CA (P＜0.05). The contents of, uric acid, urea and creatinine in SA were very significantly higher than that in CA (P＜0.01). The body weight, body fat rate and contents of HDL-C, LDL-C uric acid, urea and creatinine in SA were very significantly higher than that in SR(P＜0.01). Pathological sections of aortic arch were not observed in all groups. It indicated that under the current cooking oil intake level in China, compared with soybean blend oil, corn blend oil could significantly decrease the body weight and body fat rate, and effectively improve the level of LDL-C in serum, and reduce the risk of cardiovascular disease. Compared with corn blend oil, intake higher dose of soybean blend oil was more likely to promote obesity and cause renal function impairment. |
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