| 袁露，仇丽霞，唐晓磊.微孔草籽油软胶囊急性经口毒性试验和遗传毒性试验[J].中国油脂,2017,42(12):.[YUAN Lu1,2, QIU Lixia1,TANG Xiaolei.Acute oral toxicity test and genetic toxicity test of microporous grass seed oil soft capsule[J].China Oils and Fats,2017,42(12):.] |
| 微孔草籽油软胶囊急性经口毒性试验和遗传毒性试验 |
| Acute oral toxicity test and genetic toxicity test of microporous grass seed oil soft capsule |
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| DOI： |
| 中文关键词: 微孔草籽油软胶囊 急性经口毒性试验 遗传毒性试验 |
| 英文关键词:microporous grass seed oil soft capsule acute oral toxicity test genetic toxicity test |
| 基金项目: |
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| 中文摘要: |
| 系统研究微孔草籽油软胶囊的安全性，对微孔草籽油软胶囊进行急性经口毒性试验和遗传毒性试验（包括精子畸形试验，骨髓细胞微核试验，Ames试验）。结果表明：微孔草籽油软胶囊急性毒性最大耐受剂量（MTD）为18 g/kg，属于无毒级；遗传毒性试验结果均为阴性。根据其急性经口毒性试验、遗传毒性试验结果，可以进行下一阶段的毒性试验。 |
| 英文摘要: |
| The safety of microporous grass seed oil soft capsule was studied systematically. With microporous grass seed oil soft capsule as raw material, acute oral toxicity test and genetic toxicity test (including sperm shape abnormality test, bone marrow micronucleus test and Ames test) were carried out. The results showed that the maximum tolerance dose of acute toxicity of microporous grass seed oil soft capsule was 18 g/kg, which belonged to the non-toxic grade. The results of genetic toxicity test were negative. According to the results of acute oral toxicity test and genetic toxicity test, the next stage of toxicity test could be carried out. |
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