| 单伟达1，王丽虹2.医药级微粒状羊毛醇的制备[J].中国油脂,2024,49(4):.[SHAN Weida1, WANG Lihong2.Preparation of pharmaceutical-grade micritic lanolin alcohol[J].China Oils and Fats,2024,49(4):.] |
| 医药级微粒状羊毛醇的制备 |
| Preparation of pharmaceutical-grade micritic lanolin alcohol |
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| DOI： |
| 中文关键词: 医药级 羊毛醇 吸附剂 微粒状 |
| 英文关键词:pharmaceutical-grade lanolin alcohol adsorbent micritic |
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| 摘要点击次数: 84 |
| 全文下载次数: 65 |
| 中文摘要: |
| 为了提高日化级羊毛醇的附加值以及为大规模制备医药级羊毛醇提供技术参考，以日化级羊毛醇为原料，通过吸附剂脱色、两级分子蒸馏及冷却喷雾造粒技术制备医药级微粒状羊毛醇，对吸附剂进行筛选，考察了造粒条件对造粒合格率的影响，并对制备的医药级微粒状羊毛醇的质量指标（酸值、过氧化值、皂化值、加德纳色度）进行测定。结果表明：AB-8大孔树脂吸附脱色效果好，产品收率高；在冷却空气温度10 ℃、冷却空气湿度20%、喷雾压力0.6 MPa、喷头转速6 000 r/min的条件下，医药级微粒状羊毛醇的造粒合格率达到95.78%，所制备的医药级羊毛醇符合欧洲和美国药典对医药级羊毛醇的要求。综上，此制备方法可以得到质量合格的医药级羊毛醇。 |
| 英文摘要: |
| In order to improve the added value of daily chemical-grade lanolin alcohol and improve the technical reference for the large-scale preparation of pharmaceutical-grade lanolin alcohol, the daily chemical-grade lanolin alcohol was used as the raw material, and the pharmaceutical-grade micritic lanolin alcohol was prepared by adsorbent decolorization, two-stage molecular distillation and cooled spray pelleting. The adsorbent was screened, the influence of the pelleting conditions on the pelleting rate of conformity was investigated, and the quality indexes (acid value, peroxide value, saponification value, Gardner′s color) of the produced pharmaceutical-grade micritic lanolin alcohol were determined. The results showed that AB-8 macroporous resin had good decolorization effect and high product yield. Under the conditions of cooling air temperature 10 ℃, cooling air humidity 20%, spraying pressure 0.6 MPa, and nozzle rotational speed 6 000 r/min, the pelleting rate of conformity of pharmaceutical-grade micritic lanolin alcohol reached 95.78%, and the produced pharmaceutical-grade lanolin alcohol complied with the requirements of the Pharmacopoeia of Europe and the United States for pharmaceutical-grade lanolin alcohol. In conclusion, this method can obtain qualified pharmaceutical-grade lanolin alcohol. |
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