| 包音都古荣·金花1,2,3，宝鲁日4，和硕特麦丽斯5，侯荣伦3，呼格吉勒图3，
敖日格勒3，岩松1,2，敖日格乐1,2，周欢敏2.草原羊脑磷脂型DHA对小鼠
生理机能的影响[J].中国油脂,2025,50(3):.[BAOYINDUGURONG·Jinhua1,2,3, BAOLURI4, HESHUOTE Mailisi5，HOU Ronglun3，
HUGEJILETU3, AORIGELE3, YAN Song1, 2，AORIGELE1, 2， ZHOU Huanmin2.Effect of phospholipid-type DHA from grassland sheep brain on physiological functions of mice[J].China Oils and Fats,2025,50(3):.] |
| Effect of phospholipid-type DHA from grassland sheep brain on physiological functions of mice |
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| DOI： |
| KeyWord:grassland sheep phospholipid-type DHA organ index blood lipids liver function histological analysis Peyer′s patches |
| FundProject:内蒙古自治区自然科学基金项目（2023MS03034）；内蒙古自治区科技计划项目（2023YFDZ0050）；内蒙古自治区科技计划项目（2021GG0348）；草原英才项目（内组通字〔2021〕333号，内人才发〔2023〕3号） |
| Author Name | Affiliation | | BAOYINDUGURONG·Jinhua1,2,3, BAOLURI4, HESHUOTE Mailisi5，HOU Ronglun3，
HUGEJILETU3, AORIGELE3, YAN Song1, 2，AORIGELE1, 2， ZHOU Huanmin2 | 1．College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China
2.Inner Mongolia Key Laboratory of Biofabrication,Hohhot 010010, China
3.Inner Mongolia Hesige Agriculture and Animal Husbandry Technology Co. , Ltd. , Xilingol League 026321, Inner Mongolia, China
4.Department of Pathology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010110, China
5. Crystal Pharmatech, Inc. , New Jersey 08512, USA |
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| Abstract: |
| Aiming to provide scientific basis for the development and utilization of grassland sheep brain phospholipid-type DHA (DHA-PLs) ,the DHA-PLs was extracted from Sunite sheep brains. Based on the determination that the DHA-PLs did not carry prion protein, a total of 30 seven-week-old SPF Kunming female mice an average body mass of 27 g were selected and divided into blank group (basal feed), fish oil group (basal feed added with fish oil), and sheep brain DHA-PLs group(basal feed added with sheep brain DHA-PLs). The changes in physical signs, weekly energy discharge,crude fat content in feces, and organ indexes of the mice fed for 3 months were studied,and their serum biochemistry and liver function indexes were determined, as well as intestinal and organ tissue morphology were observed to reveal the degree of the effects of sheep brain DHA-PLs on nutrient absorption, organs, blood lipids and liver function in mice. The results showed that no prion protein in the sheep brain, and the highest normal prion protein level reached up to 200 mg/g. At the end of the 3-month feeding test, the three groups of mice were in good health, with no difference in average daily feed intake, and all of them had significantly larger final body mass (p<0.05). Compared with the blank group, the weekly energy discharge, crude fat content in feces, serum triglyceride and cholesterol contents, and the levels of aspartate aminotransferase and alanine of mice in the sheep brain DHA-PLs group were significantly reduced (p<0.05), but there was no significant difference with the fish oil group（p＞0.05）. There were no significant differences in organ indexes among the mice in the three groups（p＞0.05）, and the tissues of the heart, liver, kidneys, spleen, stomach, and brain did not show any lesions.There was no injury to the intestines of the mice in the three groups,and the ratio of villus height to crypt depth in the jejunum showed no difference between the three groups （p＞0.05）, but in the sheep brain DHA-PLs group and the fish oil group, the intestines of mice grew 14 and 13 Peyer′s patches, respectively, which did not appear in the blank group. In conclusion, DHA-PLs extracted from grassland sheep brain can promote nutrient absorption, significantly reduce blood lipids, enhance liver function, and improve intestinal immune function without adverse effects on mice organs, making them suitable for use in food and health care production. |
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