| 张艺博1，薛永常1，刘长斌1，2.微藻油脂合成的转录调控研究进展[J].中国油脂,2024,49(4):.[ZHANG Yibo1, XUE Yongchang1, LIU Changbin1，2.Advances in transcriptional regulation of lipid synthesis in microalgae[J].China Oils and Fats,2024,49(4):.] |
| 微藻油脂合成的转录调控研究进展 |
| Advances in transcriptional regulation of lipid synthesis in microalgae |
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| DOI： |
| 中文关键词: 微藻 转录因子 转录调控 油脂积累 |
| 英文关键词:microalgae transcription factors transcription regulation lipid accumulation |
| 基金项目:辽宁省教育厅2020年度科研项目（J2020113）；辽宁省市场监督管理局2022年度市场监管科技计划项目（2022ZC025） |
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| 中文摘要: |
| 生物燃料是传统化石燃料的理想替代品，微藻是生产生物燃料的优良原料,通过对微藻油脂合成和调控的了解，能够有效提高微藻生产生物柴油的效率。转录因子是一种具有特殊功能结构、行使调控基因表达功能的蛋白质分子，在复杂的油脂合成代谢过程中，转录因子能对代谢过程中多个酶系进行集体调控，从而促进藻细胞中油脂积累。从微藻油脂的合成途径出发，简要介绍了合成途径中的关键酶，重点综述了bZIP、MYB、Dof、bHLH转录因子对于微藻油脂合成的调控影响。微藻油脂合成涉及多个亚细胞单位的多条途径，是一个十分复杂的代谢网络过程，通过基因工程手段改变合成途径中相关酶的表达可以增加微藻中油脂积累。 |
| 英文摘要: |
| Biofuel is an ideal alternative to traditional fossil fuels, and microalgae is excellent raw materials for the production of biofuels. Through the understanding of the synthesis and regulation of microalgae lipid, the production efficiency of biodiesel by microalgae can be effectively improved. Transcription factors are protein molecules with special functional structures that perform the function of regulating gene expression. In the complex lipid synthesis and metabolism process, transcription factors can collectively regulate multiple enzyme lines in the metabolic process, thus promoting lipid accumulation in algal cells. The synthesis pathway of microalgae lipid was introduced, the key enzymes in the synthesis pathway were briefly introduced, and the regulation effect of bZIP, MYB, Dof and bHLH transcription factors on the microalgae lipid synthesis was reviewed. Microalgae lipid synthesis involves multiple pathways of multiple subcellular units, and is a very complex metabolic network process, and changing the expression of related enzymes in the synthetic pathways by genetic engineering means can increase lipid accumulation in microalgae. |
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