| The effects of eicosapentenoic acid (EPA)on spatial learning and memory,antioxidant capacity and serum lipid of rats were investigated. 24 weaning male SD rats were randomly divided into negative control group,low dosage EPA group(150 mg/(kg·d)), mid dosage EPA group (300 mg/(kg·d)) and high dosage EPA group(600 mg/(kg· d)).After feeding for 30 d, the Morris water maze test on the rats was conducted,and the contents of serum total cholesterol, high density lipoprotein cholesterol and triglyceride and the contents of acetylcholinesterase, nitricoxide synthase,superoxide dismutase and malondialdehyde in brain were determined.The results showed that comparing with the negative control group, the content of malondialdehyde of rats in low dosage EPA group decreased significantly; the escape latency and content of malondialdehyde of rats in high dosage EPA group remarkably increased;the activity of superoxide dismutase of rats improved while the content of malondialdehyde obviously declined in mid dosage EPA group.In conclusion,EPA could not improve the function of spatial learning and memory of rats, and high dosage EPA could reduce the function of spatial learning and memory of rats, while certain dosage of EPA could improve the level of serum lipid and antioxidant capacity of rats. |
