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| Improvement of flaxseed cake on blood lipid and oxidative stress of rats fed a high-fat diet |
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| KeyWord:flaxseed cake lipid-lowering acti vity oxidative stress |
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| Abstract: |
| The effects of flaxseed cake on lipid metabolism in plasma and antioxidant activity of rats fed a high-fat diet were studied. Forty SD rats were divided into four groups （n=10）：control group，hyperlipidemia model control group，low dose flaxseed cake group（10% flaxseed cake） and high dose flaxseed cake group（20% flaxseed cake）. The rats were sacrificed after ten weeks feeding，and the levels of total cholesterol （TC），triglyceride （TG），low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol（HDL-C）in plasma were determined，and the activities of glutathione peroxidase （GSH-Px），superoxide dismutase （SOD），catalase （CAT） as well as contents of glutathione （GSH） and malondialdehyde（MDA）in plasma were simultaneously determined. The results showed that flaxseed cake could significantly decrease the levels of TC，TG and LDL-C in plasma of SD rats，while it had no remarkable effect on the level of HDL-C；flaxseed cake could improve the activities of GSH-Px，SOD and CAT and the level of GSH，meanwhile it could reduce the content of MDA in plasma of SD rats. The results indicated that flax seed cake could reduce the harmful effects on rats caused by high-fat diet，effectively enhance the antioxidant activity，relieve oxidative stress and regulate lipid metabolism. |
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