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| 亚麻籽油微胶囊芯材的释放条件及模拟缓释行为研究 |
| Release condition and sustained-release behavior simulation of flaxseed oil microcapsule core material |
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| DOI： |
| 中文关键词: 微胶囊 动力学 共聚焦显微镜 体外释放 |
| 英文关键词:microcapsule kinetics confocal microscopy release in vitro |
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| 中文摘要: |
| 以大豆分离蛋白、麦芽糊精、亚麻籽胶为壁材，以亚麻籽油为芯材，经喷雾干燥得到亚麻籽油微胶囊产品。应用Avramis公式对微胶囊在不同温度、湿度条件下的芯材保留率进行拟合分析，拟合程度良好，R2均大于0.96，5?℃、湿度34%条件下释放速率最低，可作为合适的储藏条件；采用一级动力学对微胶囊在体外SGF（模拟胃液）、SIF（模拟胰液）中的释放情况进行研究，得出释放速率常数BSGF=2.48×10-2明显小于BSIF=4.59×10-2，表明微胶囊在SGF中有缓释行为；借助激光共聚焦显微镜对体外释放过程进行观察，近60%芯材在SIF内释放，顺应人体肠道的消化吸收规律。 |
| 英文摘要: |
| With soybean protein isolate，maltodextrin and flaxseed gum as wall materials，and flaxseed oil as core material，flaxseed oil microcapsule was prepared by spray drying.The retention rates of core material in microcapsule under different temperatures and humidities were fitted by Avramis equation，the fitting was good with R2 all above 0.96，and the release speed was the slowest under the conditions of 5?℃ and 34% of humidity，which could be used as appropriate storage condition.The releases of the microcapsule in SGF (simulated gastric fluid) and SIF (simulated pancreatic fluid) were studied in vitro by first order kinetics，and the results showed that the release speed constant BSGF(2.48×10-2) was obviously lower than BSIF (4.59×10-2)，which indicated that the microcapsule had sustained-release behavior in SGF.The release process in vitro was observed by laser confocal microscopy，and the results showed that nearly 60% of core material released in SIF，which complied with human intestinal digestion and absorption law. |
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