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| 植物油与猪油的1∶ 1调和油对小鼠血脂及肝脏脂质代谢的影响 |
| Effects of vegetable oils blended with lard in mass ratios of 1∶ 1 on blood lipid and hepatic lipid metabolism of mice |
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| DOI： |
| 中文关键词: 调和油 猪油 菜籽油 大豆油 PPARγ RXRα 血脂 抗氧化 |
| 英文关键词:blend oil lard rapeseed oil soybean oil PPAR款 RXR慣 blood lipid antioxidation |
| 基金项目: |
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| 中文摘要: |
| 以小鼠为模型模拟我国居民膳食习惯，探讨摄入不同水平的2种植物油与猪油的1∶?1调和油对其体重、血脂、肝脏抗氧化及肝脏PPARγ和RXRα mRNA表达的影响。将40只8周龄雄性KM小鼠随机平均分为空白对照组（I）、菜籽调和油低剂量组（A1）、菜籽调和油高剂量组（A2）、大豆调和油低剂量组（B1）和大豆调和油高剂量组（B2），饲喂8周后进行称重、解剖，取外周血清检测血脂，取肝脏匀浆检测氧化损伤指标以及肝脏PPARγ和RXRα mRNA表达量。结果表明：A1组TG含量极显著高于I组、A2组和B1组，PPARγ水平极显著高于I组和B1组，LDL-C水平极显著低于A2组；A2组小鼠体重增长率极显著高于I组和A1组，GSH-Px活性显著高于B2组和A1组，RXRα水平极显著高于A1组；B1组MDA含量极显著低于B2组，GSH-Px活性显著高于A1组和B2组；B2组HDL-C含量极显著高于I组和A2组，LDL-C含量极显著低于A2组，RXRα水平极显著高于I组、A2组和B1组，PPARγ水平极显著高于I组、B1组，显著高于A2组。摄入低剂量菜籽油和猪油调和油或高剂量大豆油和猪油调和油，有助于降低血脂、降低体重和保护心血管健康；摄入低剂量大豆油和猪油调和油或高剂量菜籽油和猪油调和油，有助于提高肝脏抗氧化能力，降低肝脏氧化损伤。 |
| 英文摘要: |
| The diet habits of domestic resident were simulated by mice model，and the effects of two kinds of vegetable oils blended with lard in mass ratios of 1∶?1 on the body weight，blood lipid，antioxidation and PPARγ and RXRα mRNA expressions in mice liver were investigated. Forty eight-weeks old male KM mice were randomly divided into five groups：blank group (I)，low dosage group of rapeseed blend oil (A1)，high dosage group of rapeseed blend oil (A2)，low dosage group of soybean blend oil (B1) and high dosage group of soybean blend oil (B2). After feeding for eight weeks，the mice were weighted and dissected. The peripheral blood serum was taken to detect blood lipid，and the liver homogenate was taken to detect oxidative damage index and PPARγ and RXRα mRNA expressions. The results showed that in group A1，TG content was extremely and significantly higher than that in group I，A2 and B1; PPARγ level was extremely and significantly higher than that in group I and B1; LDL-C content was extremely and significantly lower than that in group A2. In group A2，the growth rate of body weight of mice was extremely and significantly higher than that in group I and A1; the GSH-Px activity was significantly higher than that in group B2 and A1，and the RXRα level was extremely and significantly higher than that in group A1. In group B1，the MDA content was extremely and significantly lower than that in group B2，and the GSH-Px activity was significantly higher than that in group A1 and B2. In group B2，the HDL-C content was extremely and significantly higher than that in group I and A2; LDL-C content was extremely and significantly lower than that in group A2; the RXRα level was extremely and significantly higher than that in group I，A2 and B1; and the PPARγ level was extremely and significantly higher than that in group I and B1，markedly higher than that in group A2. Intake of low dosage of rapeseed oil and lard blend oil or high dosage of soybean oil and lard blend oil was beneficial for reducing blood lipid level and body weight，and protecting cardiovascular health. Intake of low dosage of soybean oil and lard blend oil or high dosage of rapeseed oil and lard blend oil was beneficial for improving hepatic antioxidant capacity and reducing hepatic oxidative damage. |
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