| The blood lipid reduction effect of watermelon seed oil on hyperlipidemia rats was investigated. 48 male Wistar rats were divided into six groups,in which the negative control group and high fat control group were intragastrically administered with distilled water daily, positive control group was intragastrically administered with Xuezhikang 0.06 g/kg daily,and three test groups were intragastrically administered with watermelon seed oil 2.6, 7.7 g/kg and 13.0 g/kg daily,respectively.The negative control group was fed with standard diet and other groups were fed with high fat diet. After 30 d of intragastric administration, the blood lipid levels of Wistar rats were determined, and the livers were taken for pathologic observation to contrast the differences of blood lipid of each group. The results showed that the total cholesterol (TC), triglyceride (TG) and low-density lipoprotein-cholesterol (LDL-C) levels of rats in three test groups were lower than those in high fat control group in different degree, while high-density lipoprotein-cholesterol (HDL-C) level was significantly higher than that in high fat control group. The levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)in serum and liver of rats in three test groups were significantly higher than those in high fat control group,but the levels of malondialdehyde (MDA) in three test groups were lower than those in high fat control group. Also the liver pathological sections showed that the fatty degeneration in three test groups was differently improved. All the results indicated that watermelon seed oil could reduce blood lipid in hyperlipidemia rats with the best effect at dose of 2.6 g/kg. |
