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| 酶法改性1，3-DG猪脂肪的安全性评价 |
| Safety assessment of enzymatic modification of 1，3-DG pig fat |
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| DOI： |
| 中文关键词: 1，3-DG猪脂肪 急性毒性 遗传毒性 28 d经口毒性 |
| 英文关键词:1,3-DG pig fat acute toxicity genetic toxicity twenty-eight days oral toxicity |
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| 中文摘要: |
| 评估酶法改性1，3-DG猪脂肪的安全性，并为其开发利用提供科学依据。依据《食品安全性毒理学评价程序和方法》，以KM小鼠和SD大鼠为受试动物进行急性毒性、遗传毒性试验（包括Ames试验、红细胞微核试验和显性致死试验）以及28 d经口毒性试验。急性毒性试验表明，经口灌胃酶法改性1，3-DG猪脂肪，未见明显异常，LD50>17 g/kg，该物质为无毒级。遗传毒性3项试验结果为阴性，未表现出致突变性。28 d经口毒性试验表明，各剂量组大鼠临床检查正常，体重、进食量、食物利用率、血常规、血生化、脏体比等各项指标均在正常范围内，与空白对照组相比差异不显著（p＞0.05）；组织病理学观察并未发现病理改变。研究表明酶法改性1，3-DG猪脂肪是安全无毒的可食用油脂。 |
| 英文摘要: |
| The safety of enzymatic modification of 1，3-DG pig fat was evaluated so as to provide scientific basis for its exploitation and utilization. According to Procedures and Methods in the Food Toxicological Safety Evaluation， a series of toxicological studies on the ingestion of 1，3-DG pig fat were conducted， including acute toxicity test， genetic toxicity tests (Ames test， erythrocyte micronucleus test and dominant lethal test)and twenty-eight days oral toxicity test with SD rats and KM mice as test animals. The results of acute toxicity test showed that there was no obviously abnormal in mice orally given of 1，3-DG pig fat and the lethal dose (LD50) was more than 17 g/kg， so it belonged to non-toxic class. The results of genetic toxicity tests were negative and it showed no mutagenicity. The results of twenty-eight days oral toxicity test showed that the growth development and behavior of the mice were normal， and the indexes including weight， food intake， food utilization， blood count， biochemical test and organ-body ratio in treatment groups were in normal ranges, which had no significant difference from those in control group(p＞0.05). There was no abnormality in the test of organ histopathology. The research indicated that enzymatic modification of 1，3-DG pig fat was a kind of edible oil without toxicity. |
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