| The protective effect of Gardenia oil on carbon tetrachloride acute liver injury in mice was studied and its protective mechanism was investigated. The activities of ALT, AST and levels of TBA, TBIL, DBIL in serum, the activities of SOD and levels of MDA and GSH in liver tissue were measured and pathological morphological in liver tissues were monitored by HE staining section in carbon tetrachloride acute liver injury mice. The protective effect of different doses group of Gardenia oil on carbon tetrachloride acute liver injury in mice was discussed. The results showed that compared with model group, middle dose group (0.6 g/kg) and high dose group (1.2 g/kg) of Gardenia oil could significantly improve the pathological changes of liver tissue in carban tertrachloride acute liver injury mice, and could significantly reduce the activities of ALT, AST and the levels of TBA, TBIL, DBIL in serum. High dose group (1.2 g/kg) of Gardenia oil could improve the SOD activity and GSH level, and reduce the MDA content in liver homogenate. Gardenia oil had a significant hepatoprotective effect on carbon tetrachloride induced liver injury mice. The mechanism might be related to enzyme decreasing, inhibition of free radical lipid peroxidation and maintenance of normal morphology of hepatic cells. |
