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| Optimization of microwave solid-phase synthesis of peanut peptide-ferrous metal coordination chelating technology by response surface methodology |
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| KeyWord:peanut peptide-ferrous coordination chelation microwave solid-phase catalysis response surface methodology optimization |
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| Abstract: |
| To promote the coordination chelation of peanut peptide and ferrous, peanut peptide (relative molecular weight less than 3.0 kD) and ferrous sulfate (FeSO4·7H2O) were used as reactant and mental chelator, respectively. A central composite design response surface methodology (CCD-RSM) was utilized to optimize peanut peptide-ferrous coordination chelation process using microwave solid-phase synthesis technology based on single factor experiment. The influences of microwave radiation time, peanut peptide-ferrous ratio and initiator dosage on peanut peptide-ferrous coordination chelation were investigated, and a second-order polynomial nonlinear regression equation and mathematical model were established. The results showed that the optimal peanut peptide-ferrous coordination chelation process conditions were obtained as follows: microwave radiation time 153 s, peanut peptide-ferrous ratio 5∶1, initiator dosage 3%, microwave radiation power 608 W, reactant particle size 120 meshes, using 2.5% of carbon-white as deacidification agent (based on the mass of peanut peptide) and 0.3% of sodium isoascorbate as ferrous protective agent (based on the mass of ferrous sulfate). Under these conditions, the chelating rate was (90.68±1.31)%, and was consistent with the predictive value (92.71%). The research indicated that microwave solid-phase synthesis technology was an efficient and promising means for the solid-phase catalytic preparation of metal nutrition supplement from peanut peptide and ferrous. |
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