| The effects of two levels of blend oil of lard and corn oil or soybean oil on body weight, body fat rate, blood lipid, blood glucose, renal function and aortic arch in mice were investigated by simulating Chinese dietary habits. A total of 40 eight weeks male C57BL/6J mice were randomly divided into four groups respectively fed with 3.8% corn oil and lard blend oil (recommended intake group,CR), 6.5% corn oil and lard blend oil (actual intake group, CA), 3.8% soybean oil and lard blend oil (recommended intake group,SR), and 6.5% soybean oil and lard blend oil (actual intake group, SA). After eight weeks, body weight was measured, peripheral blood was collected for determining blood lipid, serum glucose and renal function, and aortic arch was made HE pathology. The results showed that the body weight and body fat rate in SA were very significantly higher than that in CA (P＜0.01). The adiponcetin content in SA was very significantly lower than that in CA (P＜0.01). The SA had higher LDL-C level than CA (P＜0.05). The contents of, uric acid, urea and creatinine in SA were very significantly higher than that in CA (P＜0.01). The body weight, body fat rate and contents of HDL-C, LDL-C uric acid, urea and creatinine in SA were very significantly higher than that in SR(P＜0.01). Pathological sections of aortic arch were not observed in all groups. It indicated that under the current cooking oil intake level in China, compared with soybean blend oil, corn blend oil could significantly decrease the body weight and body fat rate, and effectively improve the level of LDL-C in serum, and reduce the risk of cardiovascular disease. Compared with corn blend oil, intake higher dose of soybean blend oil was more likely to promote obesity and cause renal function impairment. |
