| The anti-fatigue effect of medium chain triglycerides (MCT) and related mechanism were studied. 100 healthy male KM mice were randomly divided into five groups：quiet control group (CC1 and CC2), swimming control group (SC1 and SC2), low dose group (SL1 and SL2), middle dose group (SM1 and SM2) and high dose group (SH1 and SH2), each group had 20 mice, and then each group was randomly divided into two groups, each group had 10 mice. The first group of mice SC1，SL1，SM1 and SH1 would be swimming without load for 60 min after the gastric perfusion of MCT for 30 d, and then the biochemical indicators were measured. The second group of mice SC2，SL2，SM2 and SH2 would be exhausted burden swimming after the gastric perfusion of MCT for 30 d, and then the burden swimming exhaustive time was measured. The results showed that compared with swimming control group, MCT could significantly prolong the burden swimming exhaustive time, reduce the serum urea nitrogen and serum lactic acid contents, reduce blood glucose and liver glycogen consumption, improve liver SOD activity, GSH content and FFA content, reduce the content of liver MDA and increase serum LDH activity. So MCT had anti-fatigue effect, and the effect was the most obvious in low dose group. |
