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| 饲喂鱼油对小鼠干眼症的治疗及缓解作用 |
| Treatment and relief effect of fish oil diet on dry eye disease in mice |
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| DOI： |
| 中文关键词: 鱼油 干眼症 DHA |
| 英文关键词:fish oil dry eye disease DHA |
| 基金项目: |
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| 中文摘要: |
| 研究饲喂鱼油对小鼠干眼症的治疗及缓解作用。采用苯扎氯氨诱导小鼠发生干眼症，并将其随机分为对照组(棕榈油替代鱼油)及鱼油饲喂组，饲喂14 d前后分别检测两组小鼠的泪液分泌量及泪膜破裂时间；14 d后处死小鼠，取眼周腺体，气相色谱法检测其DHA含量。结果表明：与饲喂前比较，鱼油饲喂组泪液分泌量增加、泪膜破裂时间明显延长(P＜0.05)，对照组各指标变化不明显(P＞0.05)；饲喂14 d后组间比较，鱼油饲喂组泪液分泌量增加、泪膜破裂时间明显延长(P＜005)；饲喂14 d后，鱼油饲喂组眼周腺体中DHA含量极显著高于对照组(P＜0.01)；高DHA膳食可减轻苯扎氯铵诱导的干眼症小鼠的干眼症状，可能与眼部腺体中DHA的供应有关。 |
| 英文摘要: |
| The treatment and relief effect of fish oil diet on dry eye disease in mice was studied. BALB/c mice with dry eye disease induced by benzalkonium chloride were randomly divided into control group (palm oil instead of fish oil) and fish oil dietary group, and the tear secretion and tear film rupture time of these two groups of mice were measured before and after feeding for 14 d. The mice were executed after 14 d, glands on the peripheral eye was taken, and DHA content was examined by GC. The results showed that compared with mice before feeding, tear secretion increased and tear film rupture time prolonged (P＜0.05) in fish oil dietary groupthe , and these changes in control group were not obvious(P＞0.05). Compared with control group, tear secretion of fish oil dietary group increased and tear film rupture time prolonged (P＜0.05) after feeding for 14 d. And the DHA content in the periocular glands of fish oil dietary group was significantly higher than that of control group (P<0.01). High DHA dietary could relieve dry eye disease symptom of mice induced by benzalkonium chloride, and it may be related to the supply of DHA in peri ocular gland. |
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