| Dietary lipids provide abundant unsaturated fatty acids,but unsaturated fatty acids are susceptible to lipid peroxidation, with the production of reactive carbonyl pices (RCS).The representative RCS are malondialdehyde (MDA), acrolein (ACR), 4-hydroxy-2-nonenal (HNE), glyoxal (GO), etc. RCS is reactive and can make other components in food intramolecular or intermolecular cross-linking, such as proteins and nucleophilic groups in DNA, affecting the quality of food. Dietary intake and accumulation of RCS will affect the normal physiological functions of human body and pose a threat to health. Therefore, it is necessary to counteract the toxicity of RCS by blocking and eliminating RCS after generation. The origin, properties and toxicity of several representative RCS were discussed, and the types and mechnism of current RCS inhibitors were also briefly introduced, so as to have a comprehensive and in-depth understanding on the toxicity and inhibition strategy of RCS. |
