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| Antioxidant activity of Punica granatum seed oil on aging model mice induced by D-galactose |
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| KeyWord:Punica granatum seed oil D-galactose aging mice antioxidation |
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| Abstract: |
| The antioxidant activity of Punica granatum seed oil (PGSO) on aging model mice induced by D-galactose was studied. Sixty Kunming mice were randomly divided into six groups: healthy group, model group, vitamin E (VE) positive control group, and low-, medium-, and high-dose PGSO groups. After 45 d treatment, body weights of mice in each group were measured. The effects of PGSO on antioxidant system in liver, kidney, brain and serum of mice were analyzed. And the activity of G6PD and the content of NADPH in liver and kidney of mice were examined. The results showed that PGSO antagonized the decrease of body weight of mice compared with model group. In liver, kidney, brain and serum of mice, PGSO reduced the content of MDA and increased the content of GSH and activity of T-AOC, as well as the activities of antioxidant enzymes SOD and GSH-Px. In addition, in liver and kidney of mice, PGSO elevated the activity of G6PD and the content of NADPH. Taken together, the data indicated that PGSO had the capacity of antagonizing oxidative stress in aging model mice induced by D-galactose. |
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