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Friday April 4,2025,
Preparation of liposome thermosensitive gel of jujube seed oil
  
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KeyWord:jujube seed oil  liposome thermosensitive gel  sustained release
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WANG Li， ZHAO Ning， WANG Dan  
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Abstract:
      In order to improve the bioavailability of the jujube seed oil and improve its stability and sustained release, the jujube seed oil was prepared to be the liposome thermosensitive gel. By optimizing the preparation process, the encapsulation rate of jujube seed oil was 73.8%. The liposome obtained was prepared as a thermosensitive gel with a gelling temperature of 35-36?℃, with the drug-loading rate of 2.8%. The gel was liquid in the lower part of the nasal cavity at 30-33?℃. Thus it could flow into the nasal olfactory region mucous membrane which was difficult to touch, and adhere in that area with a sustained release by the form of liposome.
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