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Optimization of extraction process of Ziziphi Spinosae Semen oil by response surface methodology
  
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KeyWord:Ziziphi Spinosae Semen oil  extraction process  response surface methodology
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ZHAI Yingying，GONG Qianfeng，YU Huan，etc  
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Abstract:
      With petroleum ether as extraction solvent, the extraction of Ziziphi Spinosae Semen oil was studied by solvent method. With extraction time, extraction temperature and ratio of material to liquid as influencing factors, yield of Ziziphi Spinosae Semen oil as response value, three factors and three levels of Box-Behnken response surface methodology was conducted on the basis of single factor experiment. The results showed that the optimal extraction conditions of Ziziphi Spinosae Semen oil were obtained as follows: extraction time 6.9 h, extraction temperature 82.6?℃ and ratio of material to liquid 1∶?16.5. Under these conditions, the yield of Ziziphi Spinosae Semen oil reached 32.21%, close to 32.26% of predictive value.
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