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| Preparation of certified reference material of sesamin |
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| KeyWord:sesamin certified reference material homogeneity stability certification uncertainty |
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| Abstract: |
| A certified reference material (CRM) of sesamin was developed according to the technical requirements of CRM General and Statistical Principle for Certification (GB/T 15000.3—2008). Sesamin monomer was prepared from sesame by means of high-speed counter-current chromatography, and its structure was confirmed by UV, IR, MS and NMR. Sesamin sample was analyzed by thin layer chromatography and thermo-gravimetric analysis. Also it was tested for homogeneity test，stability test，and cooperative certification by eight laboratories. The results indicated that the homogeneity of sesamin was excellent, with good stability within 36 months at 0-4?℃. The certified value of the reference material of sesamin was 99.73% with the expanded uncertainty of 0.20 in confidence coefficient of 95%. The certified reference material of sesamin was successfully developed. It was conformed to the technical requirement of GB/T 15000.3—2008 and could be traceable. The CRM could be used in the content determination and testing method validation of sesamin related products. |
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