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Optimization of preparation of Paeonia suffruticosa seed oil inclusion complex by response surface methodology
  
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KeyWord:Paeonia suffruticosa seed oil  hydroxypropyl-β-cyclodextrin  inclusion complex  response surface methodology
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WANG Xiaoning, HAO Jing, LI Meng，etc  
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Abstract:
      The Paeonia suffruticosa seed oil-hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex was prepared by ultrasound method. Based on single factor experiment, the Box-Behnken response surface methodology was used to optimize the preparation process with the comprehensive OD value of inclusion rate and inclusion complex yield as evaluation index. The optimal preparation process conditions were obtained as follows: ultrasonic power 360 W, inclusion temperature 46.5?℃ and mass ratio of Paeonia suffruticosa seed oil to HP-β-CD 1∶?6.6. Under the optimal conditions, the inclusion complex yield, inclusion rate and OD value of the inclusion complex were 85.53%, 92.00% and 8941%, respectively. The Paeonia suffruticosa seed oil-HP-β-CD inclusion complex was formed confirmed by IR.
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