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| 牡丹籽油对环磷酰胺致小鼠遗传毒性和肝损伤的保护作用 |
| Protective effects of peony seed oil on cyclophosphamide-induced genotoxicity and liver injury in mice |
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| DOI： |
| 中文关键词: 牡丹籽油 环磷酰胺 遗传毒性 肝损伤 |
| 英文关键词:peony seed oil cyclophosphamide genotoxicity liver injury |
| 基金项目: |
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| 中文摘要: |
| 通过骨髓微核实验、精子畸形实验和肝损伤保护实验测定小鼠骨髓微核率、精子畸形率，肝组织中谷丙转氨酶（ALT）、谷草转氨酶（AST）、还原型谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）和丙二醛（MDA）等指标，探讨牡丹籽油（PSO）对环磷酰胺（CTX）致小鼠遗传毒性和肝损伤的保护作用。结果表明：低、中、高剂量PSO组的骨髓微核率和精子畸形率均显著低于模型组（P<0.05）；与模型组相比，PSO低剂量组对AST的降低无显著作用（P>0.05），阳性对照（联苯双酯）组和中、高剂量组对AST、ALT、MDA水平均有显著降低作用（P<0.05），对GSH、GSH-Px、SOD水平的升高作用达到显著水平（P<0.05）。说明牡丹籽油对环磷酰胺致小鼠遗传毒性和肝损伤有明显的保护作用。 |
| 英文摘要: |
| To study the protective effects of peony seed oil (PSO) on cyclophosphamide (CTX)-induced genotoxicity and liver injury in mice, micronucleus test, sperm abnormality test and liver injury protection test were used to determine micronucleus rate，sperm malformation rate of mice, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and malondialdehyde (MDA) levels in liver tissue of mice. The results showed that the micronucleus rate and sperm malformation rate of mice in PSO low, medium and high dose groups were significantly lower than those in model group (P<0.05). Compared with the model group, PSO low dose group had no significant effects on the reduction of AST (P>0.05), the bifendate group and PSO medium and high dose groups had significant effects on the reduction of AST, ALT and MDA levels (P<0.05) and had significant effects on the increase of GSH, GSH-Px and SOD levels (P<0.05). In summary，PSO had significant protection effect on cyclophosphamide-induced genotoxicity and liver injury in mice. |
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