| To study the protective effects of peony seed oil (PSO) on cyclophosphamide (CTX)-induced genotoxicity and liver injury in mice, micronucleus test, sperm abnormality test and liver injury protection test were used to determine micronucleus rate，sperm malformation rate of mice, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and malondialdehyde (MDA) levels in liver tissue of mice. The results showed that the micronucleus rate and sperm malformation rate of mice in PSO low, medium and high dose groups were significantly lower than those in model group (P<0.05). Compared with the model group, PSO low dose group had no significant effects on the reduction of AST (P>0.05), the bifendate group and PSO medium and high dose groups had significant effects on the reduction of AST, ALT and MDA levels (P<0.05) and had significant effects on the increase of GSH, GSH-Px and SOD levels (P<0.05). In summary，PSO had significant protection effect on cyclophosphamide-induced genotoxicity and liver injury in mice. |
