| In order to investigate the effects of trans-palmitoleic acid on metabolic homeostasis of obese mice, an obesity model induced by high-fat diet was established, and the body weight, food intake, fasting glucose, postprandial glucose, glucose sensitivity, respiratory exchange ratio (RER), heat production and activity of the mice were examined. QPCR and Western BLOT were respectively used to detect the expression of lipid-metabolism-related genes and liver inflammation-related proteins of mice. The results showed that trans-palmitoleic acid significantly improved glucose sensitivity (p<0.01), inhibited appetite (p<0.000 1), reduced subcutaneous fat accumulation (p<0.05),and enhanced respiratory metabolism (p<0.000 1) and heat production (p<0.000 1) without affecting body weight, fasting blood glucose, postprandial glucose and liver inflammation of mice, while it significantly decreased animal activity (p<0.001), finally leading to an energy balance status. In conclusion, it suggested that although as a kind of trans fatty acids, trans-palmitoleic acid had no harmful effect on the metabolism of obese mice, so it could provide a certain reference value for future research on safe dietary food additives. |
