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| Effects of gastric administration of medium-chain triglycerides with different time courses on anti-fatigue function in mice |
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| KeyWord:medium-chain triglycerides different time course anti-fatigue |
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| Abstract: |
| Effects of different time courses of gastric perfusion of medium-chain triglycerides (MCT)on the anti-fatigue function in mice were studied, also the shortest effective time of anti-fatigue effect of MCT was discussed.120 healthy male KM mice were randomly divided into six groups：quiet control group (CC1 and CC2), swimming control group (SC1 and SC2), 3 h group（TH1 and TH2）, 3 d group（TD1 and TD2）, 5 d group（FD1 and FD2）and 7 d group（SD1 and SD2）. Each group had 20 mice. Then each group was randomly divided into two groups, and each group had ten mice. The first groups were used for swimming without load for 60 min after the gastric perfusion of MCT for the corresponding time course to measure the biochemical indicators of mice. The second groups were used for loaded-swimming exhaustion after the gastric perfusion of MCT for the corresponding time course to measure the loaded-swimming exhaustion time. The results showed that acute gastric perfusion of MCT and short-time gastric perfusion of MCT could both significantly lengthen loaded-swimming exhaustion time of mice, reduce BUN content to an extend and increase liver GSH content. Besides, with the gastric perfusion time prolonging, the effects of MCT on maintaining stable blood glucose and glycogen content, lowering serum lactate content and improving liver free fatty acid content were more obvious. In conclusion, acute gastric perfusion MCT and short-time gastric perfusion MCT could improve the exercise endurance and anti-fatigue of mice, and the effect of 7 d group was the most obvious. |
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