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Effect of different ratios of linoleic acid to α-linolenic acid on inflammatory cytokines in HepG2 cells
  
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KeyWord:polyunsaturated fatty acid  ratio of LA to ALA  inflammatory cytokine
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LIU Ruijie, TA Wei, WANG Limei，etc  
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Abstract:
      The typical polyunsaturated fatty acid(PUFAs) linoleic acid(LA, n-6 PUFAs) and α-linolenic acid(ALA, n-3 PUFAs) in vegetable oils were selected to set up seven experimental groups with different molar concentration ratios (Group 1-7: LA, 10∶?1 LA/ALA, 5∶?1 LA/ALA，1∶?1 LA/ALA，1∶?5 LA/ALA，1∶?10 LA/ALA，ALA) to study the effect of different molar concentration ratios of n-6 PUFAs to n-3 PUFAs on inflammatory cytokines in HepG2 cells.The results showed that 60 μmol/L different ratios of LA to ALA could reduce the level of pro-inflammatory cytokines TNF-α and IL-6 produced by HepG2 cells, and increase the level of anti-inflammatory IL-10 and LXA4. Group 4 was the best one.
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