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| 不同比例LA/ALA对HepG2细胞炎症因子的影响 |
| Effect of different ratios of linoleic acid to α-linolenic acid on inflammatory cytokines in HepG2 cells |
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| DOI： |
| 中文关键词: 多不饱和脂肪酸 LA/ALA比例 炎症因子 |
| 英文关键词:polyunsaturated fatty acid ratio of LA to ALA inflammatory cytokine |
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| 中文摘要: |
| 选取植物油中典型的多不饱和脂肪酸亚油酸(LA)和α-亚麻酸(ALA)为原料，分为7个不同摩尔浓度配比实验组（组1，LA；组2，10∶?1 LA/ALA；组3，5∶?1 LA/ALA；组4，1∶?1 LA/ALA；组5，1∶?5 LA/ALA；组6，1∶?10 LA/ALA；组7，ALA）体外评估不同比例n-6/n-3 PUFAs对HepG2细胞炎症因子的影响。结果表明：60 μmol/L各实验组均可降低HepG2细胞产生的促炎因子TNF-α和IL-6水平，提高抗炎因子IL-10和抗炎介质LXA4水平，其中组4（1∶?1 LA/ALA）作用最显著。 |
| 英文摘要: |
| The typical polyunsaturated fatty acid(PUFAs) linoleic acid(LA, n-6 PUFAs) and α-linolenic acid(ALA, n-3 PUFAs) in vegetable oils were selected to set up seven experimental groups with different molar concentration ratios (Group 1-7: LA, 10∶?1 LA/ALA, 5∶?1 LA/ALA，1∶?1 LA/ALA，1∶?5 LA/ALA，1∶?10 LA/ALA，ALA) to study the effect of different molar concentration ratios of n-6 PUFAs to n-3 PUFAs on inflammatory cytokines in HepG2 cells.The results showed that 60 μmol/L different ratios of LA to ALA could reduce the level of pro-inflammatory cytokines TNF-α and IL-6 produced by HepG2 cells, and increase the level of anti-inflammatory IL-10 and LXA4. Group 4 was the best one. |
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