|
| Protection effect of flax lignan on AAPH-induced oxidative stress in erythrocytes and liver tissue |
| |
| DOI： |
| KeyWord:flax lignan AAPH antioxidation erythrocyte liver tissue |
| FundProject: |
|
| Hits: 1886 |
| Download times: 0 |
| Abstract: |
| In order to study the antioxidant activity and mechanism of flax lignan, its scavenging ability on DPPH free radical was determined, and the erythrocytes and liver tissue models of AAPH-damaged rats were established to research the effects of flax lignan on hemolysis rate, hemoglobin oxidation rate, malondialdehyde (MDA) and antioxidant enzymes. The results showed that flax lignan had a scavenging effect on DPPH free radical. The protective effect of flax lignan on erythrocyte hemolysis and hemoglobin oxidation was concentration-dependent, and compared with the model group treated with AAPH for 4 h, the protective effects of 50 μmol/L and 100 μmol/L flax lignan were significantly improved. In the AAPH-induced erythrocytes oxidative stress model, 100 μmol/L and 150 μmol/L flax lignan remarkably reduced the MDA content in model group treated with AAPH for 4 h, and significantly increased the activity of GSH-Px. 150 μmol/L flax lignan significantly increased the activities of SOD and CAT in the group damaged with AAPH for 2 h and 4 h. In liver tissue damaged by AAPH, flax lignan (150 μmol/L) reduced the MDA content with different damageable time (1-4 h), and increased SOD and CAT enzymes activities when AAPH damaged for 4 h. It indicated that flax lignan had antioxidative effect, and it could inhibit peroxidation of lipids, and protect antioxidative enzymes activities in erythrocytes and liver tissue. |
| View full text View/Add Comment Download reader |
| Close |
|
|
|
