| The protective effect of linseed extract on D-galactose induced subacute aging mouse model was discussed. Mice were subcutaneously injected into neck to establish aging model. Successful model mice were randomly divided into model group, high(600 mg/kg), medium(300 mg/kg) and low(150 mg/kg) dose of linseed extract groups. All mice were intragastric administration for six weeks, the thymus index and spleen index were calculated, and the MDA, SOD, CAT and GSH-Px in blood, brain, liver and kidney were analyzed. The results showed that compared with normal group, the spleen index and MDA content increased, and the thymus index,SOD,CAT and GSH-Px activities decreased, which indicated that the aging mice model was successfully established. Compared with model group, the spleen index and MDA content in blood and tissue of high dose of linseed extract group decreased significantly, and the thymus index, SOD, CAT and GSH-Px activities increased significantly. These data indicated that linseed extract had protective effect on D-galactose-induced aging mouse and its mechanism may be related with the inhibition of lipid peroxides and improvment of antioxidant enzyme activities. |
