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| 高顺式占比番茄红素纳米结构脂质载体的制备及贮藏稳定性研究 |
| Preparation and storage stability of high ratio of cis-lycopene-loaded nanostructured lipid carrier |
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| DOI： |
| 中文关键词: 高顺式占比番茄红素 纳米结构脂质载体 乳化 贮藏稳定性 |
| 英文关键词:high ratio of cis- lycopene nanostructured lipid carrier emulsification storage stability |
| 基金项目: |
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| 中文摘要: |
| 以高顺式占比番茄红素（cis-Lyco）为核心组分，筛选富含ω-3多不饱和脂肪酸的油脂为辅助性功能成分，优选天然乳化剂，采用熔融-预乳化和高压均质联用法制备高顺式占比番茄红素纳米结构脂质载体（cis-Lyco-NLC）。以cis-Lyco-NLC的平均粒径、包封率、载量为指标筛选固液脂，采用贮藏实验以cis-Lyco-NLC的物理化学稳定性为指标优选天然乳化剂。结果表明：固液脂组合为单硬脂酸甘油酯和牡丹籽油（固态脂与液态脂质量比3∶?1），乳化剂为酪蛋白酸钠时，制备的cis-Lyco-NLC的包封率高达94.6%，载量为3.72%，平均粒径为185.63 nm；35 d 的贮藏实验表明，cis-Lyco-NLC样品在4?℃的贮藏温度下能保持良好的物理稳定性（平均粒径<200 nm），且番茄红素保留率在90%以上。 |
| 英文摘要: |
| High ratio of cis- lycopene （cis-Lyco） as the core component, the oils rich in omega-3 polyunsaturated fatty acids as auxiliary functional components and preferably emulsifiers were used to prepare high cis-lycopene-loaded nanostructured lipid carrier （cis-Lyco-NLC） by melt-pre-emulsification and high pressure homogenization. The solid-liquid lipid was selected by measuring the average particle size, encapsulation efficiency and loading of cis-Lyco-NLC, and with physicochemical stability of cis-Lyco-NLC as index, the emulsifier was preferably selected by the storage experiment. The results showed that when the solid-liquid lipid combination was glycerol monostearate and peony seed oil （mass ratio of solid fat to liquid fat 3∶?1）, and the emulsifier was casein, the prepared cis-Lyco-NLC had an encapsulation efficiency of 94.6%, a loading of 3.72%, and an average particle size of 185.63 nm. The storage experiment of 35 d showed that the cis-Lyco-NLC sample maintained good physical stability at 4?℃ （average particle size <200 nm）, and the retention rate of lycopene remained above 90%. |
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