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| Preparation and storage stability of high ratio of cis-lycopene-loaded nanostructured lipid carrier |
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| KeyWord:high ratio of cis- lycopene nanostructured lipid carrier emulsification storage stability |
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| Abstract: |
| High ratio of cis- lycopene （cis-Lyco） as the core component, the oils rich in omega-3 polyunsaturated fatty acids as auxiliary functional components and preferably emulsifiers were used to prepare high cis-lycopene-loaded nanostructured lipid carrier （cis-Lyco-NLC） by melt-pre-emulsification and high pressure homogenization. The solid-liquid lipid was selected by measuring the average particle size, encapsulation efficiency and loading of cis-Lyco-NLC, and with physicochemical stability of cis-Lyco-NLC as index, the emulsifier was preferably selected by the storage experiment. The results showed that when the solid-liquid lipid combination was glycerol monostearate and peony seed oil （mass ratio of solid fat to liquid fat 3∶?1）, and the emulsifier was casein, the prepared cis-Lyco-NLC had an encapsulation efficiency of 94.6%, a loading of 3.72%, and an average particle size of 185.63 nm. The storage experiment of 35 d showed that the cis-Lyco-NLC sample maintained good physical stability at 4?℃ （average particle size <200 nm）, and the retention rate of lycopene remained above 90%. |
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