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| 支链脂肪酸及其抗炎作用研究进展 |
| Progress of branched chain fatty acids and their anti-inflammatory activities |
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| DOI： |
| 中文关键词: 支链脂肪酸 坏死性小肠结肠炎 炎症 机制研究 |
| 英文关键词:branched chain fatty acids necrotizing enterocolitis inflammation mechanism research |
| 基金项目: |
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| 中文摘要: |
| 支链脂肪酸主要是饱和脂肪酸，在其碳骨架上有1个或多个支链，支链以甲基最为常见。特殊的支链结构和饱和状态使支链脂肪酸具有独特的理化性质。支链脂肪酸与炎症关系密切，目前我国对于支链脂肪酸的研究大多还集中于牛羊类反刍动物的乳汁、肉制品上，对于与人类相关支链脂肪酸的研究还很少。综述了支链脂肪酸的结构及其分布特征，总结了支链脂肪酸的主要生理功能与机制，探究了人乳、喂养方式、新生儿坏死性小肠结肠炎与支链脂肪酸的关系。提出开发支链脂肪酸作为孕妇的膳食补充剂，或以支链脂肪酸为原料发展新型抗癌药是未来的研究方向。 |
| 英文摘要: |
| Branched chain fatty acids are mainly saturated fatty acids, which have one or more branched chains on their carbon skeletons, and methyl is the most common branched chain. Special branched structure and saturation state make branched chain fatty acid unique physicochemical properties. Branched chain fatty acids are closely related to inflammation, but most of the studies on branched chain fatty acids in China still focus on the milk and meat products of ruminants such as cattle and sheep, and there is few study on branched chain fatty acids related to humans. The structure and distribution characteristics of branched chain fatty acids, and the main physiological functions and mechanisms of branched chain fatty acids were summarized, and the relationships between breast milk, feeding mode, neonatal necrotizing enterocolitis and branched chain fatty acids were explored. It was suggested that the development of dietary supplements for pregnant women with branched chain fatty acids or the development of new anticancer drugs with branched chain fatty acids as raw materials was the future research direction. |
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