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| 月见草油透皮吸收对小鼠体重增长抑制效果的研究 |
| Inhibition effect of transdermal absorption of evening primrose oil on body weight growth of mice |
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| DOI： |
| 中文关键词: 月见草油 体重 脂肪细胞 血脂 肝脏脂肪代谢 |
| 英文关键词:evening primrose oil body weight adipocyte blood lipid hepatic fat metabolism |
| 基金项目:广东省教育厅大学生实践教学基地“中山大学药学院-广州栋方股份公司校外实践基地”项目支持 |
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| 中文摘要: |
| 以雄性BALB/C小鼠为实验对象，通过测定体重、身长、体脂质量、血脂生化指标、肝脏脂肪代谢相关基因的mRNA表达水平和观察脂肪细胞大小，评价月见草油透皮吸收后对小鼠体重增长的抑制效果。结果表明：与橄榄油组相比较，月见草油能显著抑制小鼠体重增长，明显降低生殖器周围脂肪质量、脂肪系数以及Lees指数；月见草油组小鼠的脂肪细胞直径明显变小；涂抹月见草油可降低血清中TG、TC和LDL含量，减少肝脏脂肪合成相关基因ACC、FAS、LPL、SREBP1-C和HMGCR mRNA表达水平，上调脂肪分解相关基因HSL、CPT1和LDL-R mRNA表达。月见草油透皮吸收后，可以通过调控肝脏脂肪代谢途径，促进机体脂肪氧化分解，抑制雄性小鼠的体重增长，降低血清中血脂含量。 |
| 英文摘要: |
| With male BALB/C mice as the experimental objects，the inhibition effect of transdermal absorption of evening primrose oil on the body weight growth of mice was explored by determination of body weight，body length，fat weight，blood biochemical indexes，mRNA expressions of key regulators of hepatic lipid metabolism and observation of the size of adipocytes. The results showed that compared with olive oil group，evening primrose oil could significantly inhibit the growth of body weight of mice，and lower genital surrounding fat weight，fat coefficient and Lees index. The diameters of adipocytes in evening primrose oil group were obviously smaller. The contents of TG,TC and LDL in serum and the expression levels of ACC,FAS,LPL,SREBP1-C and HMGCR mRNA decreased，and the expression levels of HSL，CPT1 and LDL-R mRNA increased by smearing evening primrose oil. After transdermal absorption of evening primrose oil，it could regulate the pathway of hepatic fat metabolism，promote the oxidative decomposition of body fat to inhibit the body weight growth of male mice and reduce the lipid content in serum. |
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