Correlation of DHA algal oil and Alzheimers disease
  
DOI:10.12166/j.zgyz.1003-7969/2019.11.024
KeyWord:DHA algal oil  Alzheimers disease  acetylcholine
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Author NameAffiliation
LI Xun1,CHEN Tao2 1.Department of Medical LaboratoryThe Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China 2.Wuhan Institute of VirologyCAS Wuhan 430071China 
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Abstract:
      The correlation of DHA algal oil and Alzheimers disease was studied by detecting acetylcholine level in brain tissue of SD rats. DHA algal oil, microbial ARA oil and peanut nutrition blend oil were blended and fed to SD rats at a dose of 3 mL/d. After eight weeks of feeding, the acetylcholine level in brain tissue of SD rats was measured. The results showed that acetylcholine levels in brain tissue of SD rats fed with negative control group(peanut nutrition blend oil), positive control group(blend oil containing pure DHA 500 mg and pure ARA 200 mg), treatment high dose group(blend oil containing pure DHA 400 mg and pure ARA 200 mg), treatment medium dose group(blend oil containing pure DHA 300 mg and pure ARA 200 mg), treatment low dose group(blend oil containing pure DHA 200 mg and pure ARA 200 mg) were(29.47±5.05),(159.05±13.41),(121.70±15.07),(86.83±9.86),(58.10±9.17) μg/mg respectively. The differences between the treatment groups and the negative control group and positive control group were very significant(P<0.01). The higher the DHA algal oil content, the stronger the acetylcholine activity in brain tissue of SD rats, indicating that DHA algal oil could relieve the symptoms of Alzheimers disease.
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