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| Enhancement of immune function of peony seed oil compound soft capsule |
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| DOI：10.12166/j.zgyz.1003-7969/2019.11.025 |
| KeyWord:peony seed oil immune function mice |
| FundProject:国家食品科学与工程一流学科建设项目（JUFSTR 20180204） |
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| Abstract: |
| The enhancement of immune function of peony seed oil compound soft capsule was investigated in vitro and in vivo. The immune enhancement ability of each component of the soft capsule was determined by lymphocyte proliferation assay in vitro. The mice were given three doses of peony seed oil compound soft capsules at 0.3，0.6，1.8 g/kg respectively for 30 d and the cellular immunity, humoral immunity, mononuclear macrophage function and NK cell activity were determined. The results showed that 4,6,8 mg/mL tea extract, 6,8 mg/mL bitter gourd extract and 8 mg/mL peony seed oil could significantly enhance lymphocyte proliferation ability in vitro of the mice(P<0.05). In vivo experiments, compared with the control group, the 1.8 g/kg group very significantly enhanced the lymphocyte proliferation ability and NK cell activity(P<0.01), and significantly enhanced the delayed hypersensitivity and carbon clearance ability of the mice（P<005); 0.6 g/kg group could very significantly enhance the NK cell activity(P<0.01), significantly enhance the lymphocyte proliferation ability and delayed hypersensitivity in mice(P<0.05); 0.3 g/kg group could significantly enhance the delayed hypersensitivity in mice(P<0.05). All the results indicated that peony seed oil compound soft capsule could enhance the immune function of mice. |
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