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| Ameliorates of oleoylethanolamide on fatty acid-induced oxidative stress in LO2 cells |
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| DOI：10.12166/j.zgyz.1003-7969/2020.10.018 |
| KeyWord:oleylethanolamide fatty acid LO2 cell oxidative stress nonalcoholic fatty liver |
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| Abstract: |
| Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most common chronic disease, and oxidative stress plays an important role in its pathogenesis and development. Oleoylethanolamide(OEA), a naturally occurring lipid signaling molecule, has a variety of pharmacological properties. The effect and mechanism of oleylethanolamide on oxidative stress in fatty acid-induced LO2 cells were investigated. The cells were induced by 0.4 mmol/L mixture of oleic acid and palmitic acid (molar ratio 2∶ 1), and then treated with different concentrations of OEA for 24 h. The results showed that OEA significantly reduced the contents of reactive oxygen species (ROS) and malondialdehyde (MDA) in LO2 cells and increased the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Further research indicated that OEA increased the expressions level of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1) protein and mRNA to ameliorate oxidative stress. |
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